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PAPSS1 Antikörper (C-Term)

This anti-PAPSS1 antibody (ABIN389138) is a Rabbit Polyclonal antibody detecting PAPSS1 in WB. Suitable for Human.
Produktnummer ABIN389138

Kurzübersicht für PAPSS1 Antikörper (C-Term) (ABIN389138)

Target

Alle PAPSS1 Antikörper anzeigen
PAPSS1 (3'-phosphoadenosine 5'-phosphosulfate Synthase 1 (PAPSS1))

Reaktivität

  • 25
  • 3
  • 2
Human

Wirt

  • 22
  • 3
Kaninchen

Klonalität

  • 23
  • 2
Polyklonal

Konjugat

  • 13
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser PAPSS1 Antikörper ist unkonjugiert

Applikation

  • 16
  • 12
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB)

Klon

RB5109
  • Bindungsspezifität

    • 7
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 592-624, C-Term

    Aufreinigung

    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

    Immunogen

    This PAPSS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 592-624 amino acids from the C-terminal region of human PAPSS1.

    Isotyp

    Ig Fraction
  • Applikationshinweise

    WB: 1:1000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

    Haltbarkeit

    6 months
  • Bergelin, Blom, Heikkilä, Löf, Alam, Balthasar, Slotte, Hinkkanen, Törnquist: "Sphingosine kinase as an oncogene: autocrine sphingosine 1-phosphate modulates ML-1 thyroid carcinoma cell migration by a mechanism dependent on protein kinase C-alpha and ERK1/2." in: Endocrinology, Vol. 150, Issue 5, pp. 2055-63, (2009) (PubMed).

  • Target

    PAPSS1 (3'-phosphoadenosine 5'-phosphosulfate Synthase 1 (PAPSS1))

    Andere Bezeichnung

    PAPSS1

    Hintergrund

    Sulfotransferase (SULT) enzymes catalyze the sulfate conjugation of many drugs, xenobiotic compounds, hormones, and neurotransmitters. 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase (PAPSS) catalyzes the biosynthesis of PAPS which serves as the universal sulfonate donor compound for all sulfotransferase reactions. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2 (603005). Bifunctional PAPSS1 is comprised of an N-terminal APS kinase domain, and a C-terminal ATP sulfurylase domain. Full-length protein has significantly less APS kinase activity than the N-terminal fragment, suggesting that the C-terminal domain exerts a regulatory role on the N-terminal APS kinase activity. In humans there are two major isoforms: PAPSS1 and PAPSS2. In brain and skin PAPSS1 is the major isoform, whereas in liver, cartilage and adrenal glands PAPSS2 isoform expression dominates. The predicted 623-amino acid protein is 98 % identical to mouse PAPS synthase. The N-terminal 268-amino acid region of human PAPS synthase resembles APS kinases from other organisms and contains 3 conserved nucleotide-binding motifs.

    Molekulargewicht

    70833

    Gen-ID

    9061

    NCBI Accession

    NP_005434

    UniProt

    O43252

    Pathways

    Glycosaminoglycan Metabolic Process, Ribonucleoside Biosynthetic Process
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