GGPS1 Antikörper (N-Term)

Produktnummer ABIN389055

Dieses Anti-GGPS1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von GGPS1 in WB und IHC (p). Geeignet für Human. Dieses Primary Antibody wurde in 1 Publikation zitiert.

Kurzübersicht für GGPS1 Antikörper (N-Term) (ABIN389055)

Target: GGPS1 (Geranylgeranyl Diphosphate Synthase 1 (GGPS1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GGPS1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB4788

Produktdetails anti-GGPS1 Antikörper

Bindungsspezifität: AA 16-46, N-Term

Homologie: B, M, Rat

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This GGPS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-46 amino acids from the N-terminal region of human GGPS1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-GGPS1 Antikörper (ABIN389055)

Iguchi, Katsuno, Niwa, Yamada, Sone, Waza, Adachi, Tanaka, Nagata, Arimura, Watanabe, Kaibuchi, Sobue: "TDP-43 depletion induces neuronal cell damage through dysregulation of Rho family GTPases." in: The Journal of biological chemistry, Vol. 284, Issue 33, pp. 22059-66, (2009) (PubMed).

Details zu GGPS1

Target: GGPS1 (Geranylgeranyl Diphosphate Synthase 1 (GGPS1))

Andere Bezeichnung: GGPS1

Hintergrund: Geranylgeranyl diphosphate (GGPP) synthase (GGPS) catalyzes the synthesis of GGPP, a molecule responsible for the C20-prenylation of protein and for the regulation of a nuclear hormone receptor. The deduced 300-amino acid human protein contains 5 conserved domains consistent with prenyltransferases. Recombinant GGPS shows enzymatic properties associated with the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. Mouse GGPS is regulated in several tissues in obesity and is induced during adipocyte differentiation. GGPS is increased 5- to 20-fold in skeletal muscle, liver, and fat of ob/ob mice. Western blot analysis detects a 2-fold overexpression of protein in muscle and fat but not in liver. Differentiation of mouse fibroblasts into adipocytes induces GGPS expression more than 20-fold.

Molekulargewicht: 34871

Gen-ID: 9453

NCBI Accession: NP_001032354

UniProt: O95749