SNAIL Antikörper (N-Term)

Produktnummer ABIN388809

Dieses Anti-SNAIL-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von SNAIL in WB und IHC (p). Geeignet für Human. Dieses Primary Antibody wurde in 26+ Publikationen zitiert.

Kurzübersicht für SNAIL Antikörper (N-Term) (ABIN388809)

Target: SNAIL (SNAI1)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SNAIL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB01400

Produktdetails anti-SNAIL Antikörper

Bindungsspezifität: AA 9-39, N-Term

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This SNAI1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 9-39 amino acids from the N-terminal region of human SNAI1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid freeze-thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

Haltbarkeit: 6 months

Referenzen für anti-SNAIL Antikörper (ABIN388809)

Chiu, Wen, Wang, Hsu, Tsai, Hung, Tseng, Shyr: "Role of estrogen receptors and Src signaling in mechanisms of bone metastasis by estrogen receptor positive breast cancers." in: Journal of translational medicine, Vol. 15, Issue 1, pp. 97, (2018) (PubMed).

Gil, Ciołczyk-Wierzbicka, Dulińska-Litewka, Laidler: "Integrin-linked kinase regulates cadherin switch in bladder cancer." in: Tumour biology, Vol. 37, Issue 11, pp. 15185-15191, (2017) (PubMed).

Ishikawa, Sreekumar, Spee, Nazari, Zhu, Kannan, Hinton: "αB-Crystallin Regulates Subretinal Fibrosis by Modulation of Epithelial-Mesenchymal Transition." in: The American journal of pathology, Vol. 186, Issue 4, pp. 859-73, (2016) (PubMed).

Nakamura, Nishikawa, Saito, Sakai, Sasaki, Hashimoto, Okamoto, Suehiro, Yamasaki, Sakaida: "Decitabine inhibits tumor cell proliferation and up-regulates e-cadherin expression in Epstein-Barr virus-associated gastric cancer." in: Journal of medical virology, (2016) (PubMed).

Wei, Zhang, Wang, Li, Wang, Sun, Shen, Yang, Zhou, Du: "FOXM1 promotes lung adenocarcinoma invasion and metastasis by upregulating SNAIL." in: International journal of biological sciences, Vol. 11, Issue 2, pp. 186-98, (2015) (PubMed).

Lee, Jeon, Ju, Jeong, Kim, Yoo, Park, Han, Kang: "Dlx-2 is implicated in TGF-?- and Wnt-induced epithelial-mesenchymal, glycolytic switch, and mitochondrial repression by Snail activation." in: International journal of oncology, Vol. 46, Issue 4, pp. 1768-80, (2015) (PubMed).

Fukui, Ogawa, Shimmura, Hatou, Ichihashi, Yaguchi, Hirayama, Kawakita, Tsubota: "Possible involvement of epithelial-mesenchymal transition in fibrosis associated with IgG4-related Mikulicz's disease." in: Modern rheumatology / the Japan Rheumatism Association, pp. 1-7, (2015) (PubMed).

Borges, Perez, Thompson, Radisky, Geiger, Storz: "Effective Targeting of Estrogen Receptor-Negative Breast Cancers with the Protein Kinase D Inhibitor CRT0066101." in: Molecular cancer therapeutics, Vol. 14, Issue 6, pp. 1306-16, (2015) (PubMed).

Liang, Wang, Zhu, Yang, An, Li, Niu, Chen, Tian: "BMP-7 attenuated silica-induced pulmonary fibrosis through modulation of the balance between TGF-?/Smad and BMP-7/Smad signaling pathway." in: Chemico-biological interactions, (2015) (PubMed).

Li, Jia, Ren, Liu, Gong, Wang, Zhang, Zhao: "Axl mediates tumor invasion and chemosensitivity through PI3K/Akt signaling pathway and is transcriptionally regulated by slug in breast carcinoma." in: IUBMB life, Vol. 66, Issue 7, pp. 507-18, (2014) (PubMed).

Chen, Miyazaki, Nishizawa, Kurahashi, Leach, Wang: "MTA3 regulates CGB5 and Snail genes in trophoblast." in: Biochemical and biophysical research communications, Vol. 433, Issue 4, pp. 379-84, (2013) (PubMed).

Sehrawat, Kim, Vogt, Singh: "Suppression of FOXQ1 in benzyl isothiocyanate-mediated inhibition of epithelial-mesenchymal transition in human breast cancer cells." in: Carcinogenesis, Vol. 34, Issue 4, pp. 864-73, (2013) (PubMed).

Muenst, Däster, Obermann, Droeser, Weber, von Holzen, Gao, Viehl, Oertli, Soysal: "Nuclear expression of snail is an independent negative prognostic factor in human breast cancer." in: Disease markers, Vol. 35, Issue 5, pp. 337-44, (2013) (PubMed).

Giner, Machado, Noguera, Villamon, Pellin, Calabuig-Fariñas, Peydro-Olaya, Navarro, Llombart-Bosch: "The epithelial mesenchymal transition process in wilms tumor: a study based on a xenograft model." in: Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry, Vol. 19, Issue 4, pp. 369-75, (2011) (PubMed).

Cheng, Auersperg, Leung: "Inhibition of p53 induces invasion of serous borderline ovarian tumor cells by accentuating PI3K/Akt-mediated suppression of E-cadherin." in: Oncogene, Vol. 30, Issue 9, pp. 1020-31, (2011) (PubMed).

Pham, Chen, Li, King, Angst, Dawson, Park, Reber, Hines, Eibl: "Loss of 15-hydroxyprostaglandin dehydrogenase increases prostaglandin E2 in pancreatic tumors." in: Pancreas, Vol. 39, Issue 3, pp. 332-9, (2010) (PubMed).

Matsuura, Chiang, Lai, He, Wang, Ramkumar, Uchida, Ryo, Lu, Liu: "Pin1 promotes transforming growth factor-beta-induced migration and invasion." in: The Journal of biological chemistry, Vol. 285, Issue 3, pp. 1754-64, (2010) (PubMed).

Arimoto-Ishida, Sakata, Sawada, Nakayama, Nishimoto, Mabuchi, Takeda, Yamamoto, Isobe, Okamoto, Lengyel, Suehara, Morishige, Kimura: "Up-regulation of alpha5-integrin by E-cadherin loss in hypoxia and its key role in the migration of extravillous trophoblast cells during early implantation." in: Endocrinology, Vol. 150, Issue 9, pp. 4306-15, (2009) (PubMed).

Ogawa, Shimmura, Kawakita, Yoshida, Kawakami, Tsubota: "Epithelial mesenchymal transition in human ocular chronic graft-versus-host disease." in: The American journal of pathology, Vol. 175, Issue 6, pp. 2372-81, (2009) (PubMed).

Kim, Choi, Choi, Cheong, Kim, Kwon, Kim, Choi: "Anti-invasive activity of histone deacetylase inhibitors via the induction of Egr-1 and the modulation of tight junction-related proteins in human hepatocarcinoma cells." in: BMB reports, Vol. 42, Issue 10, pp. 655-60, (2009) (PubMed).

Details zu SNAIL

Target: SNAIL (SNAI1)

Andere Bezeichnung: SNAI1

Hintergrund: The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo.

Molekulargewicht: 29083

NCBI Accession: NP_005976

UniProt: O95863

Pathways: Negative Regulation of intrinsic apoptotic Signaling