SLUG Antikörper (N-Term)

Produktnummer ABIN388808

Es sind 5+ Publikationen für dieses Produkt verfügbar. Der Kaninchen Polyklonal anti-SLUG Antikörper wird verwendet zum Nachweis von SLUG in Proben von Human. Er wurde validiert für WB.

Kurzübersicht für SLUG Antikörper (N-Term) (ABIN388808)

Target: SLUG (SNAI2) (Snail Family Zinc Finger 2 (SNAI2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SLUG Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB15389

Produktdetails anti-SLUG Antikörper

Bindungsspezifität: AA 1-30, N-Term

Homologie: B, M, Rat

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This SLUG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human SLUG.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C.

Haltbarkeit: 6 months

Referenzen für anti-SLUG Antikörper (ABIN388808)

Liang, Wang, Li, Yu, Zhang, Li: "miR-33a suppresses the nuclear translocation of ?-catenin to enhance gemcitabine sensitivity in human pancreatic cancer cells." in: Tumour biology, (2015) (PubMed).

Huo, Kao, Chuu: "Androgen receptor inhibits epithelial-mesenchymal transition, migration, and invasion of PC-3 prostate cancer cells." in: Cancer letters, Vol. 369, Issue 1, pp. 103-11, (2015) (PubMed).

Huang, Chen, Chang, Yuan, Jeng: "Hepatocyte growth factor activates Wnt pathway by transcriptional activation of LEF1 to facilitate tumor invasion." in: Carcinogenesis, Vol. 33, Issue 6, pp. 1142-8, (2012) (PubMed).

Collado, Thiede, Baker, Askew, Igbani, Corwin: "The postnatal accumulation of junctional E-cadherin is inversely correlated with the capacity for supporting cells to convert directly into sensory hair cells in mammalian balance organs." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 31, Issue 33, pp. 11855-66, (2011) (PubMed).

Fu, Lv, Lin, Wu, Wang, Zhou, Zhang, Wang, Tsang, Zhu, Wang: "Ubiquitin ligase cullin 7 induces epithelial-mesenchymal transition in human choriocarcinoma cells." in: The Journal of biological chemistry, Vol. 285, Issue 14, pp. 10870-9, (2010) (PubMed).

Details zu SLUG

Target: SLUG (SNAI2) (Snail Family Zinc Finger 2 (SNAI2))

Andere Bezeichnung: SLUG

Hintergrund: SLUG is a member of the Snail family of C2H2-type zinc finger transcription factors. This protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in the gene encoding SLUG may be associated with sporadic cases of neural tube defects.

Molekulargewicht: 29986

NCBI Accession: NP_003059

UniProt: O43623