TXN Antikörper (N-Term)

Produktnummer ABIN388136

Der Kaninchen Polyklonal Anti-TXN-Antikörper wurde für WB validiert. Er ist geeignet, TXN in Proben von Human zu detektieren.

Kurzübersicht für TXN Antikörper (N-Term) (ABIN388136)

Target: TXN (Thioredoxin (TXN))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TXN Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB5217

Produktdetails anti-TXN Antikörper

Bindungsspezifität: AA 1-30, N-Term

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This Thioredoxin (TRX) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human Thioredoxin (TRX).

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Details zu TXN

Target: TXN (Thioredoxin (TXN))

Andere Bezeichnung: Thioredoxin (TRX)

Hintergrund: Thioredoxins (Trx) are small, multi-functional proteins with oxidoreductase activity and are ubiquitous in essentially all living cells. Trx contains a redox active disulfide/dithiol group within the conserved Cys-Gly-Pro-Cys active site. The two cysteine residues in the conserved active centers can be oxidized to form intramolecular disulfide bonds. Reduction of the active site disulfide in oxidized Trx is catalyzed by Trx reductase with NADPH as the electron donor. The reduced Trx is a hydrogen donor for ribonucleotide reductase, the essential enzyme for DNA synthesis, and a potent general protein disulfide reductase with numerous functions in growth and redox regulations. Specific protein disulfide targets for reduction by Trx include protein disulfide isomerase(PDI) and a number of transcription factors such as p53, NF-kB and AP-1.Trx is also capable of removing H2O2, particularly when it is coupled with either methionine sulfoxide reductase or several isoforms of peroxiredoxins.

Molekulargewicht: 11737

Gen-ID: 7295

NCBI Accession: NP_001231867, NP_003320

UniProt: P10599

Pathways: Carbohydrate Homeostasis, Cell RedoxHomeostasis