SENP1 Antikörper (C-Term)

Produktnummer ABIN388043

Der Kaninchen Polyklonal Anti-SENP1-Antikörper wurde für WB validiert. Er ist geeignet, SENP1 in Proben von Human zu detektieren. Es sind 2+ Publikationen verfügbar.

Kurzübersicht für SENP1 Antikörper (C-Term) (ABIN388043)

Target: SENP1 (SUMO1/sentrin Specific Peptidase 1 (SENP1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SENP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB00649-RB0650

Produktdetails anti-SENP1 Antikörper

Bindungsspezifität: AA 560-590, C-Term

Homologie: M

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This SENP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 560-590 amino acids from the C-terminal region of human SENP1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-SENP1 Antikörper (ABIN388043)

Rohira, Chen, Allen, Johnson: "Covalent small ubiquitin-like modifier (SUMO) modification of Maf1 protein controls RNA polymerase III-dependent transcription repression." in: The Journal of biological chemistry, Vol. 288, Issue 26, pp. 19288-95, (2013) (PubMed).

Meinecke, Cinski, Baier, Peters, Dankbar, Wille, Drynda, Mendoza, Gay, Hay, Ink, Gay, Pap: "Modification of nuclear PML protein by SUMO-1 regulates Fas-induced apoptosis in rheumatoid arthritis synovial fibroblasts." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 12, pp. 5073-8, (2007) (PubMed).

Details zu SENP1

Target: SENP1 (SUMO1/sentrin Specific Peptidase 1 (SENP1))

Andere Bezeichnung: SENP1

Hintergrund: SENP1 is a protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. SENP deconjugates SUMO1 from HIPK2 and from HDAC1, which decreases the transcriptional repression activity of the latter.

Molekulargewicht: 73481

Gen-ID: 29843

NCBI Accession: NP_001254523, NP_001254524

UniProt: Q9P0U3

Pathways: Positive Regulation of Endopeptidase Activity