PRDM14 Antikörper (N-Term)

Produktnummer ABIN388018

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch PRDM14 in WB, IF und IHC (p). Er zeigt eine Reaktivität gegenüber Human und wurde in 4+ Publikationen erwähnt.

Kurzübersicht für PRDM14 Antikörper (N-Term) (ABIN388018)

Target: PRDM14 (PR Domain Containing 14 (PRDM14))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRDM14 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB1405

Produktdetails anti-PRDM14 Antikörper

Bindungsspezifität: AA 1-30, N-Term

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This PRDM14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human PRDM14.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: IF: 1:10~50. WB: 1:1000. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-PRDM14 Antikörper (ABIN388018)

Sugawa, Araúzo-Bravo, Yoon, Kim, Aramaki, Wu, Stehling, Psathaki, Hübner, Schöler: "Human primordial germ cell commitment in vitro associates with a unique PRDM14 expression profile." in: The EMBO journal, Vol. 34, Issue 8, pp. 1009-24, (2015) (PubMed).

Tsuneyoshi, Sumi, Onda, Nojima, Nakatsuji, Suemori: "PRDM14 suppresses expression of differentiation marker genes in human embryonic stem cells." in: Biochemical and biophysical research communications, Vol. 367, Issue 4, pp. 899-905, (2008) (PubMed).

Watanabe, Toyota, Kondo, Suzuki, Imai, Ohe-Toyota, Maruyama, Nojima, Sasaki, Sekido, Hiratsuka, Shinomura, Imai, Itoh, Tokino: "PRDM5 identified as a target of epigenetic silencing in colorectal and gastric cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 13, Issue 16, pp. 4786-94, (2007) (PubMed).

Nishikawa, Toyota, Suzuki, Honma, Fujikane, Ohmura, Nishidate, Ohe-Toyota, Maruyama, Sonoda, Sasaki, Urano, Imai, Hirata, Tokino: "Gene amplification and overexpression of PRDM14 in breast cancers." in: Cancer research, Vol. 67, Issue 20, pp. 9649-57, (2007) (PubMed).

Details zu PRDM14

Target: PRDM14 (PR Domain Containing 14 (PRDM14))

Andere Bezeichnung: PRDM14 (PFM11)

Hintergrund: Similar to acetylation and phosphorylation, histone methylation at the N terminal tail has emerged as an important role in regulating chromatin dynamics and gene activity. Histone methylation occurs on arginine and lysine residues and is catalyzed by two families of proteins, the protein arginine methyltransferase family and the SET domain containing methyltransferase family. Five members have been identified in the arginine methyltransferase family. About 27 are grouped into the SET domain family, and another 17 make up the PR domain family that is related to the SET domain family. PRDM14 is part of a family of PR domain genes that are involved in tumorigenesis. It may function as a transcription factor.

Molekulargewicht: 64062

Gen-ID: 63978

NCBI Accession: NP_078780

UniProt: Q9GZV8