HDAC9 Antikörper (N-Term)

Produktnummer ABIN387960

Dieses Anti-HDAC9-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von HDAC9 in WB, IF, IP und IHC (p). Geeignet für Human. Dieses Primary Antibody wurde in 3+ Publikationen zitiert.

Kurzübersicht für HDAC9 Antikörper (N-Term) (ABIN387960)

Target: HDAC9 (Histone Deacetylase 9 (HDAC9))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HDAC9 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB2582

Produktdetails anti-HDAC9 Antikörper

Bindungsspezifität: AA 2-32, N-Term

Homologie: C, M

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This HDAC9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-32 amino acids from the N-terminal region of human HDAC9.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: IF: 1:1,000. IP: 1:100. WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-HDAC9 Antikörper (ABIN387960)

Salian-Mehta, Xu, McKinsey, Tobet, Wierman: "Novel Interaction of Class IIb Histone Deacetylase 6 (HDAC6) with Class IIa HDAC9 Controls Gonadotropin Releasing Hormone (GnRH) Neuronal Cell Survival and Movement." in: The Journal of biological chemistry, Vol. 290, Issue 22, pp. 14045-56, (2015) (PubMed).

Sugo, Oshiro, Takemura, Kobayashi, Kohno, Uesaka, Song, Yamamoto: "Nucleocytoplasmic translocation of HDAC9 regulates gene expression and dendritic growth in developing cortical neurons." in: The European journal of neuroscience, Vol. 31, Issue 9, pp. 1521-32, (2010) (PubMed).

Deng, Ewton, Mercer, Friedman: "Mirk/dyrk1B decreases the nuclear accumulation of class II histone deacetylases during skeletal muscle differentiation." in: The Journal of biological chemistry, Vol. 280, Issue 6, pp. 4894-905, (2005) (PubMed).

Details zu HDAC9

Target: HDAC9 (Histone Deacetylase 9 (HDAC9))

Andere Bezeichnung: HDAC9

Hintergrund: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined.

Molekulargewicht: 111297

Gen-ID: 9734

NCBI Accession: NP_001191073, NP_001191074, NP_001191075, NP_001191076, NP_001191077, NP_055522, NP_478056, NP_848510, NP_848512

UniProt: Q9UKV0

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development