DNMT3A Antikörper (AA 457-486)

Produktnummer ABIN387882

Zitiert in 2+ Publikationen. Der Kaninchen Polyklonal anti-DNMT3A Antikörper (Klon RB15269) (ABIN387882) detektiert spezifisch DNMT3A in WB und IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für DNMT3A Antikörper (AA 457-486) (ABIN387882)

Target: DNMT3A (DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DNMT3A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB15269

Produktdetails anti-DNMT3A Antikörper

Bindungsspezifität: AA 457-486

Homologie: C, M, Rat

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Dnmt3a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 457-486 amino acids from the Central region of human Dnmt3a.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-DNMT3A Antikörper (ABIN387882)

Husni, Shiba-Ishii, Iiyama, Shiozawa, Kim, Nakagawa, Sato, Kano, Minami, Noguchi: "DNMT3a expression pattern and its prognostic value in lung adenocarcinoma." in: Lung cancer (Amsterdam, Netherlands), Vol. 97, pp. 59-65, (2017) (PubMed).

Chestnut, Chang, Price, Lesuisse, Wong, Martin: "Epigenetic regulation of motor neuron cell death through DNA methylation." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 31, Issue 46, pp. 16619-36, (2011) (PubMed).

Details zu DNMT3A

Target: DNMT3A (DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A))

Andere Bezeichnung: Dnmt3a

Hintergrund: CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. Dnmt3a is a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated.

Molekulargewicht: 101858

Gen-ID: 1788

NCBI Accession: NP_072046, NP_715640, NP_783328, NP_783329

UniProt: Q9Y6K1