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DNMT1 Antikörper (C-Term)

DNMT1 Reaktivität: Human WB, FACS Wirt: Kaninchen Polyclonal RB01848 unconjugated
Produktnummer ABIN387878
  • Target Alle DNMT1 Antikörper anzeigen
    DNMT1 (DNA (Cytosine-5)-Methyltransferase 1 (DNMT1))
    Bindungsspezifität
    • 27
    • 22
    • 16
    • 13
    • 12
    • 12
    • 10
    • 8
    • 8
    • 7
    • 7
    • 7
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1588-1616, C-Term
    Reaktivität
    • 203
    • 56
    • 46
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 155
    • 48
    • 1
    • 1
    Kaninchen
    Klonalität
    • 143
    • 62
    Polyklonal
    Konjugat
    • 81
    • 17
    • 14
    • 12
    • 10
    • 10
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser DNMT1 Antikörper ist unkonjugiert
    Applikation
    • 133
    • 68
    • 46
    • 42
    • 33
    • 32
    • 28
    • 17
    • 17
    • 15
    • 14
    • 14
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS)
    Aufreinigung
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This Dnmt1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1588-1616 amino acids from the C-terminal region of human Dnmt1.
    Klon
    RB01848
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product DNMT1 Primärantikörper
  • Applikationshinweise
    WB: 1:1000. FC: 1:10~50
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Bing, Zhu, Yu, Li, Liu, Li, Wang, Qi, Guo, Yuan, He, Liu, Liu: "Glucocorticoid-induced S-adenosylmethionine enhances the interferon signaling pathway by restoring STAT1 protein methylation in hepatitis B virus-infected cells." in: The Journal of biological chemistry, Vol. 289, Issue 47, pp. 32639-55, (2014) (PubMed).

    Li, Weyand, Goronzy: "Epigenetic mechanisms of age-dependent KIR2DL4 expression in T cells." in: Journal of leukocyte biology, Vol. 84, Issue 3, pp. 824-34, (2008) (PubMed).

  • Target
    DNMT1 (DNA (Cytosine-5)-Methyltransferase 1 (DNMT1))
    Andere Bezeichnung
    DNMT1 (DNMT1 Produkte)
    Synonyme
    cb1075 antikoerper, cb983 antikoerper, dmnt1 antikoerper, fb05h01 antikoerper, mta antikoerper, wu:fb05h01 antikoerper, ADCADN antikoerper, AIM antikoerper, CXXC9 antikoerper, DNMT antikoerper, HSN1E antikoerper, MCMT antikoerper, DDM2 antikoerper, DECREASED DNA METHYLATION 2 antikoerper, DMT01 antikoerper, DMT1 antikoerper, DNA METHYLTRANSFERASE antikoerper, DNA METHYLTRANSFERASE 01 antikoerper, DNA METHYLTRANSFERASE 1 antikoerper, MET2 antikoerper, METHYLTRANSFERASE 2 antikoerper, METHYLTRANSFERASE I antikoerper, METI antikoerper, methyltransferase 1 antikoerper, Cxxc9 antikoerper, Dnmt antikoerper, Dnmt1o antikoerper, MTase antikoerper, Met-1 antikoerper, Met1 antikoerper, MommeD2 antikoerper, m.MmuI antikoerper, DNA methyltransferase 1 antikoerper, DNA (cytosine-5-)-methyltransferase 1 antikoerper, methyltransferase 1 antikoerper, DNA methyltransferase (cytosine-5) 1 antikoerper, DNMT1 antikoerper, dnmt1 antikoerper, Dnmt1 antikoerper, MET1 antikoerper
    Hintergrund
    Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, 3 families of mammalian DNA methyltransferase genes have been identified which include Dnmt1, Dnmt2 and Dnmt3. Dnmt1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality. Dnmt2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintenance of methylation. The Dnmt3 family members, Dnmt3a and Dnmt3b, are strongly expressed in ES cells but their expression is down regulated in differentiating ES cells and is low in adult somatic tissue. Dnmt1 co-purifies with the retinoblastoma (Rb) tumour suppressor gene product, E2F1, and HDAC1. Dnmt1 also cooperates with Rb to repress transcription from promoters containing E2Fbinding sites suggesting a link between DNA methylation, histone deacetylase and sequence-specific DNA binding activity, as well as a growth-regulatory pathway that is disrupted in nearly all cancer cells.
    Molekulargewicht
    183165
    Gen-ID
    1786
    NCBI Accession
    NP_001124295, NP_001370
    UniProt
    P26358
    Pathways
    SARS-CoV-2 Protein Interaktom, Phosphorylierungen bei SARS-CoV-2 Infektion
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