LRRK2 Antikörper (C-Term)

Produktnummer ABIN387804

Dieses Anti-LRRK2-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von LRRK2 in . Geeignet für Human und Maus. Dieses Primary Antibody wurde in 2+ Publikationen zitiert.

Kurzübersicht für LRRK2 Antikörper (C-Term) (ABIN387804)

Target: LRRK2 (Leucine-Rich Repeat Kinase 2 (LRRK2))

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser LRRK2 Antikörper ist unkonjugiert

Applikation: Bitte anfragen

Klon: 133AT1218

Produktdetails anti-LRRK2 Antikörper

Bindungsspezifität: C-Term

Aufreinigung: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This PARK8 (LRRK2) antibody was raised in mice using purified His-tagged recombinant protein comprised of the C-terminal 261 residues of LRRK2.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: IHC: 1:50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-LRRK2 Antikörper (ABIN387804)

Ortiz-Ortiz, Morán, Ruiz-Mesa, Niso-Santano, Bravo-SanPedro, Gómez-Sánchez, González-Polo, Fuentes: "Curcumin exposure induces expression of the Parkinson's disease-associated leucine-rich repeat kinase 2 (LRRK2) in rat mesencephalic cells." in: Neuroscience letters, Vol. 468, Issue 2, pp. 120-4, (2009) (PubMed).

Biskup, Moore, Rea, Lorenz-Deperieux, Coombes, Dawson, Dawson, West: "Dynamic and redundant regulation of LRRK2 and LRRK1 expression." in: BMC neuroscience, Vol. 8, pp. 102, (2008) (PubMed).

Details zu LRRK2

Target: LRRK2 (Leucine-Rich Repeat Kinase 2 (LRRK2))

Andere Bezeichnung: PARK8 (LRRK2)

Hintergrund: This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8.

Molekulargewicht: 286103

Gen-ID: 120892

NCBI Accession: NP_940980

UniProt: Q5S007

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Skeletal Muscle Fiber Development