Selectin E/CD62e Antikörper (FITC)

Produktnummer ABIN379974

Produktdetails anti-Selectin E/CD62e Antikörper (FITC)

Target: Selectin E/CD62e (SELE) (Selectin E (SELE))

Reaktivität: Human

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser Selectin E/CD62e Antikörper ist konjugiert mit FITC

Applikation: Bitte anfragen

Spezifität: The antigen is CD62E, the epitope has not been characterized. Antigen distribution: Isolated cells: Positive on LPS, TNFa, IL-1, or TPA stimulated endothelial cells (HUVECs) in tissue culture. No cross reactivity with other cell types known. Tissue sections: Strongly positive on human endothelial cells in acutely inflamed tissues such as atopic dermatitis or contact dermatitis 24h after sensitization, in the healthy spleen and lymph node. Few single cells express the 4D10 antigen. The antigen is generally absent in chronically inflamed tissues. Biochemistry: The antigen is a 589 amino acid transmembrane protein. It consists of a C-type lectin-like domain, an epidermal growth factor (EGF)-like domain, six short consensus repeat (SCR) domains, a transmembrane domain and a cytoplasmic tail. CD62E is a counter-receptor for sialyl Lewis X, sialyl Lewis a and CLA (cutaneous lymphocyte antigen). It is involved in adhesion between myeloid cells and activated endothelium, and supports leucocytes rolling. Some skin-associated memory T cells express CLA, and it may be that CD62E is also involved in their homing to cutaneous sites of chronic inflammation. In addition, CD62E may also be involved in tumour metastasis. A soluble form of CD62E has been reported to mediate angiogenesis in pathological disorders. Specificity: Human: CD62E. Other: Not tested.

Aufreinigung: Affinity purified

Immunogen: LPS-stimulated human endothelial cells

Klon: 4D10

Anwendungsinformationen

Applikationshinweise: Usage: The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: PBS  pH 7.2, 10 mg/mL BSA, 0.1 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 4°C.

Details zu Selectin E/CD62e

Target: Selectin E/CD62e (SELE) (Selectin E (SELE))

Andere Bezeichnung: SELE / CD62E / E-selectin (SELE Produkte)

Synonyme: SELE antikoerper, CD62E antikoerper, ELAM antikoerper, ELAM1 antikoerper, ESEL antikoerper, LECAM2 antikoerper, E-selectin antikoerper, Elam antikoerper, selectin E antikoerper, selectin, endothelial cell antikoerper, SELE antikoerper, Sele antikoerper

Hintergrund: Name/Gene ID: SELE

Synonyms: SELE, CD62E, ELAM, ESEL, E-selectin, LECAM2, CD62E antigen, ELAM-1, ELAM1, Selectin E

Gen-ID: 6401

UniProt: P16581

Pathways: Thromboxane A2 Receptor Signaling