ICAM1 Antikörper

Produktnummer ABIN375487

Dieser Ratte Monoklonal Antikörper detektiert spezifisch ICAM1 in WB, FACS, IP, ICC, IHC (fro), BR und Purif. Es zeigt Reaktivität gegenüber Proben von Maus und Schwein.

Kurzübersicht für ICAM1 Antikörper (ABIN375487)

Target: ICAM1 (Intercellular Adhesion Molecule 1 (ICAM1))

Reaktivität: Maus, Schwein

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser ICAM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Blocking Reagent (BR), Purification (Purif)

Klon: YN1-1-7-4

Produktdetails anti-ICAM1 Antikörper

Verwendungszweck: Rat Anti-Mouse CD54-LE/AF

Spezifität: Mouse/Porcine CD54, Mr 95 kDa

Produktmerkmale: Low Endotoxin/Azide Free Anti-Mouse CD54 antibody for use in flow cytometry, immunohistochemistry / immunocytochemistry, western blotting, immunoprecipitation, blocking, and purification assays.

Endotoxin-Niveau: Low Endotoxin

Immunogen: Mouse NS-1 cells

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Phosphate buffered saline, pH 7.4

Konservierungsmittel: Azide free

Handhabung: Each reagent is stable for the period shown on the bottle label if stored as directed.

Lagerung: 4 °C

Informationen zur Lagerung: 2-8°C

Details zu ICAM1

Target: ICAM1 (Intercellular Adhesion Molecule 1 (ICAM1))

Andere Bezeichnung: CD54

Hintergrund: CD54, a member of the immunoglobulin superfamily of cell surface receptors and also known as Intercellular Adhesion Molecule-1 (ICAM-1), is a type I transmembrane glycoprotein that mediates important cell/cell interactions. CD54 is expressed on endothelial cells, dendritic cells, keratinocytes and lymphocytes. Its expression is upregulated by inflammatory mediators such as IFN- γ, IL-1, TNF- α, lipopolysaccharide and phorbol esters. Endothelial CD54 contributes to the extravasation of leukocytes from blood vessels, particularly in areas of inflammation. CD54 on antigen-presenting cells contributes to antigen-specific T-cell activation, presumably by enhancing interactions between T cell and antigen-presenting cells. These adhesion reactions are mediated via the binding of CD54 to its major ligands, LFA-1 and Mac-1.

Gen-ID: 15894

UniProt: P13597

Pathways: Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis, Regulation of Leukocyte Mediated Immunity, Thromboxane A2 Receptor Signaling