BDKRB1 Antikörper (Internal Region)

Produktnummer ABIN375179

Es gibt 1 Publikation für dieses Produkt. Der Ziege Polyklonal anti-BDKRB1 Antikörper wird verwendet zum Nachweis von BDKRB1 in Proben von Human. Er wurde validiert für WB und EIA.

Kurzübersicht für BDKRB1 Antikörper (Internal Region) (ABIN375179)

Target: BDKRB1 (Bradykinin Receptor B1 (BDKRB1))

Reaktivität: Human

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser BDKRB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-BDKRB1 Antikörper

Bindungsspezifität: Internal Region

Spezifität: This antibody reacts to Bradykinin receptor B1.

Aufreinigung: Affinity chromatography

Immunogen: Peptide with sequence KVWELYKQCTPK, from the internal region of the protein sequence

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: 1/1000. Western Blot: 2 - 4 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0,5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Referenzen für anti-BDKRB1 Antikörper (ABIN375179)

Wu, Roks, Leijten, Garrelds, Musterd-Bhaggoe, van den Bogaerdt, de Maat, Simoons, Danser, Oeseburg: "Genetic variation and gender determine bradykinin type 1 receptor responses in human tissue: implications for the ACE-inhibitor-induced effects in patients with coronary artery disease." in: Clinical science (London, England : 1979), Vol. 126, Issue 6, pp. 441-9, (2014) (PubMed).

Details zu BDKRB1

Target: BDKRB1 (Bradykinin Receptor B1 (BDKRB1))

Andere Bezeichnung: BDKRB1

Hintergrund: Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. Bradykinin B1 receptor is generally only minimally expressed under normal physiological conditions, but the expression is induced rapidly under pathologic conditions such as ischemia, atheromatous disease, or exposure to inflammatory cytokines.Synonyms: B1 bradykinin receptor, B1R, BK-1 receptor, BKB1R, BKR1, BRADYB1, Bradykinin B1 Receptor

Gen-ID: 623

NCBI Accession: NP_000701

UniProt: P46663

Pathways: ACE Inhibitor Pathway