Biglycan Antikörper (C-Term)

Produktnummer ABIN375174

Der Ziege Polyklonal anti-Biglycan Antikörper (ABIN375174) detektiert spezifisch Biglycan in WB und EIA. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Ratte, Maus und Hund.

Kurzübersicht für Biglycan Antikörper (C-Term) (ABIN375174)

Target: Biglycan (BGN)

Reaktivität: Human, Ratte, Maus, Hund

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser Biglycan Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-Biglycan Antikörper

Bindungsspezifität: C-Term

Sequenz: C-DRLAIQFGNY KK

Spezifität: This antibody recognizes Biglycan Preproprotein.

Kreuzreaktivität (Details): Species reactivity (expected):Mouse, Canine.
Species reactivity (tested):Human, Rat.

Aufreinigung: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide

Immunogen: Synthetic peptide from the C-Terminus of Human Biglycan (NP_001702.1) Genename: BGN

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: 1/8000. Western Blot: 0.1 - 0.3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu Biglycan

Target: Biglycan (BGN)

Andere Bezeichnung: Biglycan

Hintergrund: Biglycan is an extracellular matrix proteoglycan that is closely related in structure to decorin and fibromodulin. Biglycan and decorin are thought to be the result of a gene duplication. Biglycan is expressed in secondary myotubes during fetal muscle formation. In adult muscle it is located in the endomysium and neuromuscular junctions, where it connects to the dystrophin-associated proteins through binding to a-dystroglycan. In developing newborn mice biglycan expression is initially high and then decreases during skeletal muscle differentiation and maturation. Biglycan may also have a role in the fibrotic process since it is overexpressed in atherosclerotic lesions and has been shown to cause an increase in thymidine incorporation and migration of vascular smooth muscle cells.Synonyms: BGN, Bone/cartilage proteoglycan I, PG-S1, PGS1, SLRR1A, Small Leucine-rich Protein 1A

Molekulargewicht: 41.7 kDa (Human NP_001702.1 and Rat NP_058783.1)

Gen-ID: 633

NCBI Accession: NP_001702

UniProt: P21810

Pathways: Glycosaminoglycan Metabolic Process