Granulin Antikörper (Internal Region)

Produktnummer ABIN375134

Der Ziege Polyklonal Anti-Granulin-Antikörper wurde für WB validiert. Er ist geeignet, Granulin in Proben von Human zu detektieren.

Kurzübersicht für Granulin Antikörper (Internal Region) (ABIN375134)

Target: Granulin (GRN)

Reaktivität: Human

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser Granulin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Granulin Antikörper

Bindungsspezifität: Internal Region

Spezifität: This antibody recognizes Granulin / GRN.

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: Affinity Chromatography

Immunogen: Peptide with sequence QSKCLSKENATTD, from the internal region of the protein sequence according to NP_002078.1.

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: 1/8000. Western Blot: 1 - 3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu Granulin

Target: Granulin (GRN)

Andere Bezeichnung: Granulins (GRN)

Hintergrund: Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth. Tissue specificity: In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney. Involvement in disease: Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD) [MIM:607485], also known as tau-negative frontotemporal dementia linked to chromosome 17. Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease.Synonyms: GRN, Granulins, PEPI, Proepithelin

Molekulargewicht: 63.5 kDa (NP_002078.1)

Gen-ID: 2896, 9606

UniProt: P28799