SLC47A1 Antikörper (Internal Region)

Produktnummer ABIN375104

Der Ziege Polyklonal anti-SLC47A1 Antikörper wird verwendet zum Nachweis von SLC47A1 in Proben von Human. Er wurde validiert für WB.

Kurzübersicht für SLC47A1 Antikörper (Internal Region) (ABIN375104)

Target: SLC47A1 (Solute Carrier Family 47, Member 1 (SLC47A1))

Reaktivität: Human

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser SLC47A1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-SLC47A1 Antikörper

Bindungsspezifität: Internal Region

Sequenz: C-PEHPQDGAKL SRKQ

Spezifität: This antibody is specific to SLC47A1/MATE-1 (Internal).

Aufreinigung: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography.

Immunogen: Peptide with sequence from the internal region (near C-Terminus) of the protein sequence according to NP_060712.2.

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: Antibody detection limit dilution 1/64,000. Western Blot: (0.1-0.3 μg/mL)A approx. 60 kDa band is observed in Human Kidney lysates. An additional band of unknownidentity was also consistently observed at 20 kDa. This band was successfully blocked byincubation with the immunizing peptide.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu SLC47A1

Target: SLC47A1 (Solute Carrier Family 47, Member 1 (SLC47A1))

Andere Bezeichnung: SLC47A1

Hintergrund: Transporters are expressed in a wide variety of tissues where they perform the critical function of enabling anionic and cationic chemicals of exogenous and endogenous origin to cross otherwise impermeable cell membranes. The multidrug and toxin extrusion (MATE) transporters mediate cellular efflux of a variety of organic cations, including many drugs, and are involved in excretion of toxic electrolytes through urine and bile. Members of the MATE family share homology with the bacterial MATE protein family, which is responsible for drug resistance. MATE1 (multidrug and toxin extrusion protein 1), also known as SLC47A1, is a 570 amino acid multi-pass membrane protein that predominantly localizes to the plasma membrane but is also found in intracellular organelles. Expressed in adrenal gland, and to a lower extent in liver, skeletal muscle and kidney, MATE1 is responsible for the secretion of cationic drugs across the brush border membranes. MATE1 exists as three isoforms, which are produced by alternative splicing events.Synonyms: MATE-1, MATE1, Multidrug and toxin extrusion protein 1, Solute carrier family 47 member 1

Gen-ID: 55244, 9606

UniProt: Q96FL8