MBNL1 Antikörper (C-Term)

Produktnummer ABIN375072

Produktdetails anti-MBNL1 Antikörper

Target: MBNL1 (Muscleblind-like Protein 1 (MBNL1))

Bindungsspezifität: C-Term

Reaktivität: Human, Ratte, Maus, Hund, Rind (Kuh)

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser MBNL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: This antibody reacts to MBNL1.

Kreuzreaktivität (Details): Species reactivity (expected):Mouse, Rat, Canine, Bovine.
Species reactivity (tested):Human.

Aufreinigung: Affinity chromatography

Immunogen: Peptide with sequence C-SAEHLTSHKYVTQ, from the C Terminus of the protein sequence

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: 1/4000. Western Blot: 1 - 3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0,5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu MBNL1

Target: MBNL1 (Muscleblind-like Protein 1 (MBNL1))

Andere Bezeichnung: MBNL1 (MBNL1 Produkte)

Synonyme: MBNL1 antikoerper, zgc:153954 antikoerper, Mbnl antikoerper, mKIAA0428 antikoerper, EXP antikoerper, EXP35 antikoerper, EXP40 antikoerper, EXP42 antikoerper, MBNL antikoerper, muscleblind like splicing regulator 1 antikoerper, muscleblind-like splicing regulator 1 antikoerper, muscleblind like splicing factor 1 antikoerper, MBNL1 antikoerper, mbnl1 antikoerper, Mbnl1 antikoerper

Hintergrund: Muscleblind 1 (MBNL1) binds to the CUG triplet expansion in dsRNA. It appears to play a role in RNA splicing. Several important human diseases are associated with expansion of polynucleotide sequences, in most cases trinucleotide repeats. Myotonic dystrophy (DM1) is one of these diseases, and is associated with increases in the number of CTG repeats in the 3' UTR of the gene encoding myotonin (a.k.a. DM Kinase, DMK or myotonin-Protein Kinase), a ser/thr kinase expressed specifically in muscle. Mammalian genomes contain three muscleblind-like proteins, generally referred to as MBNL1, MBNL2 and MBNL3, and all three were found to associate with long double stranded CUG RNA repeats, thus being triplet repeat expansion dsRNA-binding proteins.Synonyms: EXP, Muscleblind-like protein 1

Gen-ID: 4154, 9606

UniProt: Q9NR56

Pathways: Ribonucleoprotein Complex Subunit Organization