PC Antikörper (Internal Region)

Produktnummer ABIN374944

Dieser Ziege Polyklonal Antikörper detektiert spezifisch PC in WB. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte, Schwein, Rind (Kuh) und Hund.

Kurzübersicht für PC Antikörper (Internal Region) (ABIN374944)

Target: PC (Pyruvate Carboxylase (PC))

Reaktivität: Human, Maus, Ratte, Schwein, Rind (Kuh), Hund

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser PC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PC Antikörper

Bindungsspezifität: Internal Region

Sequenz: C-KFKEVKKAYV EANQ

Spezifität: Recognizes Pyruvate Carboxylase (PC).

Kreuzreaktivität (Details): Species reactivity (expected):Human, Rat, Canine, Bovine, Porcine.
Species reactivity (tested):Mouse.

Aufreinigung: Affinity Chromatography

Immunogen: Peptide with sequence from the internal region of the protein sequence according to NP_000911.2, NP_001035806.1 and NP_071504.2.

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: 1/16000. Western Blot: 0.03 - 0.1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu PC

Target: PC (Pyruvate Carboxylase (PC))

Andere Bezeichnung: Pyruvic Carboxylase (PC)

Hintergrund: Pyruvate Carboxylase (PC, PCB) requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. PCB is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene.Synonyms: PCB, Pyruvate carboxylase mitochondrial

Molekulargewicht: 130kDa (NP_000911.2, NP_001035806.1 and NP_071504.2).

Gen-ID: 5091, 9606

UniProt: P11498