CPT1A Antikörper (Internal Region)

Produktnummer ABIN374737

Dieser Ziege Polyklonal Antikörper detektiert spezifisch CPT1A in WB und IHC (p). Es zeigt Reaktivität gegenüber Proben von Human.Es wurde in 1 Publikation zitiert.

Kurzübersicht für CPT1A Antikörper (Internal Region) (ABIN374737)

Target: CPT1A (Carnitine Palmitoyltransferase 1A (Liver) (CPT1A))

Reaktivität: Human

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser CPT1A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-CPT1A Antikörper

Bindungsspezifität: Internal Region

Spezifität: This antibody reacts to CPT1A. But is not expected to recognise CPT1B.

Aufreinigung: Affinity chromatography

Immunogen: Peptide with sequence C-DPAQTVEQRLKLFK, from the internal region of the protein sequence

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: 1/128000. Western Blot: 0.1 - 0.3 μg/mL. Immunohistochemistryon paraffin sections: 4 - 6 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Referenzen für anti-CPT1A Antikörper (ABIN374737)

Patsoukis, Bardhan, Chatterjee, Sari, Liu, Bell, Karoly, Freeman, Petkova, Seth, Li, Boussiotis: "PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation." in: Nature communications, Vol. 6, pp. 6692, (2015) (PubMed).

Details zu CPT1A

Target: CPT1A (Carnitine Palmitoyltransferase 1A (Liver) (CPT1A))

Andere Bezeichnung: CPT1A / CPT1-L

Hintergrund: Carnitine palmitoyltransferase 1A (CPT1A) is involved in the mitochondrial oxidation of long chain fatty acids. The oxidation of long chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine acylcarnitine translocase. CPT I is the key enzyme in the carnitine dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta oxidation.Synonyms: Carnitine O-palmitoyltransferase 1 liver isoform, Carnitine palmitoyltransferase 1A

Gen-ID: 1374, 9606

UniProt: P50416

Pathways: AMPK Signaling, Regulation of Lipid Metabolism by PPARalpha, Feeding Behaviour, Monocarboxylic Acid Catabolic Process