CBX5 Antikörper (Internal Region)

Produktnummer ABIN374617

Produktdetails anti-CBX5 Antikörper

Target: CBX5 (Chromobox Homolog 5 (CBX5))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Hund

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser CBX5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody recognizes Human Chromobox protein homolog 5 (CBX5).

Kreuzreaktivität (Details): Species reactivity (expected):Mouse, Rat.
Species reactivity (tested):Human.

Aufreinigung: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide

Immunogen: Peptide with sequence C-NKRKSNFSNSADDIK, from the internal region of the protein sequence according to NP_036249.1, NP_001120793.1, NP_001120794.1. .Remarks: Variants (NP_036249.1, NP_001120793.1, NP_001120794.1) encode the same protein

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: 1/128000. Western Blot: 0.03 - 0.1 μg/mL. Immunohistochemistry on paraffin sections: 2 - 3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu CBX5

Target: CBX5 (Chromobox Homolog 5 (CBX5))

Andere Bezeichnung: CBX5 (CBX5 Produkte)

Synonyme: HP1 antikoerper, HP1A antikoerper, id:ibd2026 antikoerper, wu:fc63e02 antikoerper, wu:fe47g12 antikoerper, wu:fi03h05 antikoerper, zgc:158601 antikoerper, CBX5 antikoerper, cbx5 antikoerper, MGC64354 antikoerper, 2610029O15Rik antikoerper, C75991 antikoerper, Hp1a antikoerper, Hp1alpha antikoerper, chromobox 5 antikoerper, chromobox homolog 5 (HP1 alpha homolog, Drosophila) antikoerper, chromobox 5 S homeolog antikoerper, CBX5 antikoerper, cbx5 antikoerper, Cbx5 antikoerper, cbx5.S antikoerper

Hintergrund: HP1 alpha is a component of heterochromatin. It recognizes and binds histone H3 tails methylated at Lys-9, leading to epigenetic repression. HP1 alpha may interact with lamin B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. HP1 proteins are relatively small proteins (~25 kDa) with a conserved amino-terminal chromo domain and a structurally related carboxy-terminal motif, the chromo shadow domain. Both domains of HP1 are required for binding to native chromatin in vivo, but they contribute differentially to binding in euchromatin and heterochromatin.Synonyms: Chromobox protein homolog 5, HP1 alpha, HP1-alpha, HP1A, Heterochromatin protein 1 homolog alpha, p25

Molekulargewicht: 22.2 kDa (NP_036249.1)

Gen-ID: 23468, 9606

UniProt: P45973