PARD6A Antikörper (C-Term)

Produktnummer ABIN374388

Produktdetails anti-PARD6A Antikörper

Target: PARD6A (Par-6 Partitioning Defective 6 Homolog alpha (PARD6A))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser PARD6A Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Sequenz: C-GSRIRGDGSG FSL

Spezifität: This antibody detects PARD6A at C-term. It is expected to recognise both reported isoforms (NP_058644.1, NP_001032358.1).

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: Immunoaffinity Chromatography

Immunogen: Syntehtic Peptide from C-Terminus of Human PARD6A Genename: PARD6A

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: antibody detection limit dilution 1: 8000. Immunohistochemistry: 5-10 μg/mL. In paraffin embedded Human Pancreas, shows strongcytoplasmic staining in rare cells of intralobular ducts. Recommended concentration,10 μg/mL. Also tested in paraffin embedded Human Heart where it shows speckled stainingon myocardial fibres in transverse section.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3, 0.02 % Sodium Azide, 0.5 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu PARD6A

Target: PARD6A (Par-6 Partitioning Defective 6 Homolog alpha (PARD6A))

Andere Bezeichnung: PARD6A (PARD6A Produkte)

Synonyme: PARD6A antikoerper, 0710008C04Rik antikoerper, 2610010A15Rik antikoerper, PAR6alpha antikoerper, Par-6 antikoerper, Par6 antikoerper, Par6c antikoerper, TAX40 antikoerper, Tip-40 antikoerper, Par-6a antikoerper, Par6a antikoerper, PAR-6A antikoerper, PAR6 antikoerper, PAR6C antikoerper, TIP-40 antikoerper, par-6 partitioning defective 6 homolog alpha (C. elegans) antikoerper, par-6 family cell polarity regulator alpha antikoerper, Partitioning defective protein 6 antikoerper, PARD6A antikoerper, Pard6a antikoerper, par-6 antikoerper

Hintergrund: PAR6 is a cell membrane protein involved in cell polarization and asymmetrical cell division processes as part of a multi protein complex. It is thought to be involved in the invasive phenotype that is associated with metastatic carcinomas, playing a role in the epithelial to mesenchymal transition (EMT). PAR6 is also thought to be involved in the formation of epithelial tight junctions. PAR6 contains a semi Cdc42/Rac interactive binding (CRIB) domain and a PDZ (PSD95/Discs-large/ZO1) domain, and several different PAR6 isoforms have been identified.Synonyms: PAR-6, PAR-6 alpha, PAR-6A, PAR6A, PAR6C, Partitioning defective 6 homolog alpha, TIP-40, Tax interaction protein 40

Gen-ID: 50855

NCBI Accession: NP_058644

UniProt: Q9NPB6

Pathways: Cell-Cell Junction Organization