ALS2 Antikörper (C-Term)

Produktnummer ABIN374168

Der Ziege Polyklonal anti-ALS2 Antikörper wird verwendet zum Nachweis von ALS2 in Proben von Human, Maus, Ratte, Rind (Kuh) und Hund. Er wurde validiert für IHC (p).

Kurzübersicht für ALS2 Antikörper (C-Term) (ABIN374168)

Target: ALS2 (Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser ALS2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-ALS2 Antikörper

Bindungsspezifität: C-Term

Sequenz: LKACYYQIQR EKLN

Spezifität: This antibody detects Alsin / ALS2 at C-term.

Aufreinigung: Ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Immunogen: Peptide from C Terminus of the protein sequence according to NP_065970.2 Genename: ALS2

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: Limit dilution 1: 8000. Immunohistochemistry: 3-5 μg/mL. In paraffin embedded Human Cortex shows pixulatecytoplasm staining in some neuronal cells.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C.

Details zu ALS2

Target: ALS2 (Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2))

Andere Bezeichnung: Alsin / ALS2

Hintergrund: ALS2 specifically binds to, and functions as a guanine nucleotide exchange factor (GEF) for the small GTPase RAB5. ALS2 contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Loss of ALS2 function might underlie neuronal dysfunction and degeneration in a number of motor neuron diseases.Synonyms: ALS2CR6, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein, Amyotrophic lateral sclerosis protein 2, KIAA1563

Gen-ID: 57679

NCBI Accession: NP_065970

UniProt: Q96Q42

Pathways: Skeletal Muscle Fiber Development