TFEC Antikörper (Internal Region)

Produktnummer ABIN372800

Der Ziege Polyklonal anti-TFEC Antikörper wird verwendet zum Nachweis von TFEC in Proben von Maus und Ratte. Er wurde validiert für IHC (p) und EIA.

Kurzübersicht für TFEC Antikörper (Internal Region) (ABIN372800)

Target: TFEC (Transcription Factor EC (TFEC))

Reaktivität: Maus, Ratte

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser TFEC Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-TFEC Antikörper

Bindungsspezifität: Internal Region

Spezifität: Recognizes Transcription Factor EC (TFEC).

Kreuzreaktivität (Details): Species reactivity (expected):Rat.
Species reactivity (tested):Mouse.

Aufreinigung: Immunoaffinity Chromatography.

Immunogen: Synthetic peptide (C-HITKQQTHPERN) from an Internal region of Mouse TFEC.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA: 1/32000. Immunohistochemistry on Paraffin Sections: 5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Tris saline buffer, pH 7.3 containing 0.5 % BSA as stabilizer and 0.02 % Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Details zu TFEC

Target: TFEC (Transcription Factor EC (TFEC))

Andere Bezeichnung: TFEC

Hintergrund: The DNA-binding factor TFE3 contains adjacent helix-loop-helix (HLH) and leucine zipper (LZ) domains flanked by an upstream basic region. These protein motifs are frequently observed in other transcription factors and are particularly common to members of the Myc family. TFE3 is ubiquitously expressed and can directly associates with DNA as either homodimers or heterodimers formed with two related proteins, TFEB or TFEC. TFE3 binds to and activates the microE3 motif of the immunoglobulin heavy-chain enhancer to induce B-cell-specific gene transcription and DNA recombination. TFEB binds to the major late promoter of adenovirus and specifically associates with DNA as both a homodimer and a heterodimer with TFE3. TFEB is expressed at low levels in the embryo but at high levels in the trophoblast cells of the placenta, where it plays a critical role in regulating normal vascularization of the placenta. TFEC shares a bHLH/LZ structure with TFE3 and a closely related protein microphthalmia-associated transcription factor (MITF), which is critically involved in melanocyte differentiation. Unlike TFE3, the expression of TFEC is largely restricted to fibroblasts, myoblasts, chondrosarcoma cells, and myeloma cells.Synonyms: TCFEC, TFE-C, TFEC-L, TFECL, Transcription factor EC, Transcription factor EC-like

Gen-ID: 21426

NCBI Accession: NP_112475

UniProt: Q9WTW4