PNPLA2 Antikörper (Internal Region)

Produktnummer ABIN372772

Dieser Ziege Polyklonal Antikörper detektiert spezifisch PNPLA2 in IHC (p) und EIA. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für PNPLA2 Antikörper (Internal Region) (ABIN372772)

Target: PNPLA2 (Patatin-Like phospholipase Domain Containing 2 (PNPLA2))

Reaktivität: Human, Maus, Ratte

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser PNPLA2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-PNPLA2 Antikörper

Bindungsspezifität: Internal Region

Spezifität: Recognizes Patatin-Like Phospholipase Domain Containing 2 (PNPLA2).

Kreuzreaktivität (Details): Species reactivity (expected):Human and Rat.
Species reactivity (tested):Mouse.

Aufreinigung: Immunoaffinity Chromatography.

Immunogen: Synthetic peptide (C-NIIEVSKEARKR) from an internal region of Mouse PNPLA2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA: 1/32000. Immunohistochemistry on Paraffin Sections: 2.5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline buffer, pH 7.3 containing 0.5 % BSA as stabilizer and 0.02 % Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Details zu PNPLA2

Target: PNPLA2 (Patatin-Like phospholipase Domain Containing 2 (PNPLA2))

Andere Bezeichnung: PNPLA2 / ATGL

Hintergrund: Adipose triglyceride lipase (ATGL) may function as a lipase and play a role in the adaptive response to a low energy state, such as fasting, by providing fatty acids to other tissues for oxidation. In addition, decreased expression of desnutrin in obesity models suggests its possible contribution to the pathophysiology of obesity. ATGL catalyzes the initial step in triglyceride hydrolysis in mammalian adipose tissue. ATGL contains a patatin domain common to plant acyl hydrolases. ATGL is highly expressed in adipose tissue of mice and humans. It exhibits high substrate specificity for triacylglycerol and is associated with lipid droplets. Inhibition of ATGL markedly decreases total adipose acyl hydrolase activity. Thus, ATGL and HSL coordinately catabolize stored triglycerides in adipose tissue of mammalsSynonyms: Adipose triglyceride lipase, Calcium-independent phospholipase A2, Desnutrin, FP17548, IPLA2-zeta, Patatin-like phospholipase domain-containing protein 2, Pigment epithelium-derived factor, TTS2.2, Transport-secretion protein 2

Gen-ID: 57104

NCBI Accession: NP_065109

UniProt: Q96AD5