UCHL1 Antikörper

Produktnummer ABIN372739

Dieses Huhn Polyklonal-Antikörper erkennt spezifisch UCHL1 in WB, IF und IHC (fro). Er zeigt eine Reaktivität gegenüber Human, Ratte, Maus, Rind (Kuh) und Säugetier.

Kurzübersicht für UCHL1 Antikörper (ABIN372739)

Target: UCHL1 (Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1))

Reaktivität: Human, Ratte, Maus, Rind (Kuh), Säugetier

Wirt: Huhn

Klonalität: Polyklonal

Konjugat: Dieser UCHL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-UCHL1 Antikörper

Spezifität: Specific for the the ~24 kDa UCHL1 protein.

Kreuzreaktivität (Details): Species reactivity (expected):Mamalia.
Species reactivity (tested):Bovine, Human, Mouse and Rat.

Aufreinigung: Ig Fraction

Immunogen: Recombinant full length human UCHL1 purified from E. coli.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Western blotting: 1/2,500. Immunofluorescence: 1/500. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody undiluted (in aliquots) at-20 °C.

Details zu UCHL1

Target: UCHL1 (Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1))

Andere Bezeichnung: UCHL1 / PGP9.5

Hintergrund: Ubiquitin C-terminal hydrolase 1 (UCHL1) is also known as ubiquitin carboxyl esterase L1, ubiquitin thiolesterase, neuron-specific protein PGP9.5 and Park5. It was originally identified as a major component of the neuronal cytoplasm from 2-dimensional gel analysis of brain tissues, and was given the name PGP9.5 (1). It was later found that ubiquitin C-terminal hydrolase enzyme activity was associated with the PGP9.5 protein (2). The ubiquitin C-terminal hydrolases cleave ubiquitin from other molecules. Regulation of the ubiquitin pathway is very important and many disease states are associated with defects in this pathway. Genetic knockout of UCHL1 in mice results in a motor neuron degeneration similar to the spontaneous gracile axonal dystrophy (gad) mutant mice (3). Point mutations in the UCHL1 gene are associated with some forms of human Parkinson's disease (4). Since UCHL1 is heavily expressed in neurons, it is released in large amounts following injury or degeneration, so the detection of UCHL1 in CSF and other bodily fluids can be used as a biomarker.Synonyms: Neuron cytoplasmic protein 9.5, PGP 9.5, UCH-L1, Ubiquitin carboxyl-terminal hydrolase isozyme L1, Ubiquitin thioesterase L1

Gen-ID: 7345

NCBI Accession: NP_004172

UniProt: P09936

Pathways: Feeding Behaviour