Der Kaninchen-Polyklonal Anti-SYT1-Antikörper wurde für WB, IHC (fro) und DB validiert. Er ist geeignet zum Nachweis von SYT1 in Proben aus Human, Ratte, Maus, Rind (Kuh), Huhn, Hund, Zebrafisch (Danio rerio) und Non-Human Primate.
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Dot blot: 1/1,000. Western blot: 1/1,000. Immunohistochemistry: 1/400. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Buffer
10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
Handhabung
Avoid repeated freezing and thawing.
Lagerung
-20 °C
Informationen zur Lagerung
Store the antibody undiluted (in aliquots) at-20 °C.
Target
SYT1
(Synaptotagmin I (SYT1))
Andere Bezeichnung
Synaptotagmin-1
Hintergrund
Synaptotagmin is widely regarded as the primary calcium sensor for synaptic vesicle exocytosis (Fernandez-Chacon et al., 2001, Wang et al., 2003). Moreover, recent studies indicate that the protein also plays a key role in endocytosis (Poskanzer et al., 2003). Synaptotagmin can be phosphorylated by multiple protein kinases and this may play a key role in modulation of synaptotagmin's ability to influence both the exocytotic and endocytotic components of synaptic transmission (Hilfiker et al., 1999, Lee et al., 2004).Synonyms: SYT1, SYT2, SYT3, SYT4, SYT5