GRM1a / GRM5 Antikörper (C-Term)

Produktnummer ABIN372670

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch GRM1a / GRM5 in WB und IHC (fro). Es zeigt Reaktivität gegenüber Proben von Ratte, Human und Maus.

Kurzübersicht für GRM1a / GRM5 Antikörper (C-Term) (ABIN372670)

Target: GRM1a / GRM5 (GRM5/1a) (Glutamate Receptor, Metabotropic 5/1a (GRM5/1a))

Reaktivität: Ratte, Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GRM1a / GRM5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-GRM1a / GRM5 Antikörper

Bindungsspezifität: C-Term

Kreuzreaktivität (Details): Species reactivity (expected):Human and Mouse.
Species reactivity (tested):Rat.

Aufreinigung: Affinity Chromatography.

Immunogen: Peptide from the C-terminal region of rat mGluR5 and rat mGluR1a.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot: 1/1000. Immunohistochemistry: 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody undiluted (in aliquots) at-20 °C.

Details zu GRM1a / GRM5

Target: GRM1a / GRM5 (GRM5/1a) (Glutamate Receptor, Metabotropic 5/1a (GRM5/1a))

Andere Bezeichnung: mGluR5/1a

Hintergrund: The metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse (Bhattacharya et al., 2004, Francesconi et al., 2004, Wilson and Nicoll, 2001). Group I metabotropic glutamate receptors (consisting of mGluR1 and mGluR5) are G-protein-coupled neurotransmitter receptors that are localized in the perisynaptic region of the postsynaptic membrane. When activated, Group I mGluRs lead to stimulation of phospholipase and activation of Protein Kinase C. In contrast, activation of Group II metabotropic receptors (mGluR2 and mGluR3) leads to inhibition of adenylate cyclase. The mGluR1 receptor may also be critically involved in limiting the deleterious effects of excitotoxicity (Blaabjerg et al., 2003). In contrast, the mGluR5 receptor appears to be essential for late phase LTP in area CA1 of the hippocampus (Francesconi et al., 2004).Synonyms: GRM1A, GRM5, MGLUR1a, MGLUR5, Metabotropic Glutamate Receptor 5/1a