GABBR1 Antikörper (pSer923)

Produktnummer ABIN372645

Dieser Anti-GABBR1-Antikörper ist ein Kaninchen-Polyklonal-Antikörper zum Nachweis von GABBR1 in WB. Geeignet für Human, Ratte, Maus, Rind (Kuh) und Non-Human Primate.

Kurzübersicht für GABBR1 Antikörper (pSer923) (ABIN372645)

Target: GABBR1 (gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1))

Reaktivität: Human, Ratte, Maus, Rind (Kuh), Non-Human Primate

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GABBR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-GABBR1 Antikörper

Bindungsspezifität: pSer923

Spezifität: Specific for ~102k GABAB R1 phosphorylated at Ser923. Immunolabeling of the GABAB R1 band is completely blocked by lambda-phosphatase treatment.

Kreuzreaktivität (Details): Species reactivity (expected):Human, Bovine, Mouse and non-Human Primates.
Species reactivity (tested):Rat.

Aufreinigung: Sequential Chromatography on phospho- and dephospho-peptide affinity columns.

Immunogen: Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser923 of GABAB R1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot: 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody undiluted (in aliquots) at-20 °C.

Details zu GABBR1

Target: GABBR1 (gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1))

Andere Bezeichnung: GABBR1

Hintergrund: Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAB receptors are heterodimeric G protein-coupled receptors that mediate slow synaptic inhibition in the central nervous system. Phosphorylation enhances GABAB receptor effector coupling (Couve et al., 2004). Phosphorylation of Ser923 is thought to be important in the regulation of GABAB receptor function.Synonyms: GABA-B receptor 1, GABA-B-R1, GABA-BR1, GABABR1, GPRC3A, Gamma-aminobutyric acid type B receptor subunit 1, Gb1

Gen-ID: 81657

NCBI Accession: NP_112290

UniProt: Q9Z0U4

Pathways: Positive Regulation of Peptide Hormone Secretion, cAMP Metabolic Process