SIRT7 Antikörper (AA 35-51, AA 361-377)

Produktnummer ABIN372439

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch SIRT7 in WB und IHC (p). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für SIRT7 Antikörper (AA 35-51, AA 361-377) (ABIN372439)

Target: SIRT7 (Sirtuin 7 (SIRT7))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SIRT7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-SIRT7 Antikörper

Bindungsspezifität: AA 35-51, AA 361-377

Spezifität: This antibody recognizes Sirtuin Type 7 (SIRT7).

Aufreinigung: Protein G Chromatography.

Immunogen: A mixture of synthetic peptides corresponding to amino acids 35-51 and 361-377 of human SIRT7.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry on Paraffin Sections: 5 μg/mL. Western blot: 1-3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS containing 0.2 % Gelatin as stabilizer and 0.05 % Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Details zu SIRT7

Target: SIRT7 (Sirtuin 7 (SIRT7))

Andere Bezeichnung: SIRT7

Hintergrund: SIRT7 is a human member of a family of proteins called Sirtuins (Sir2-like proteins) and are present in prokaryotes and eukaryotes. All Sir2-like proteins have a sirtuin core domain, which contains a series of sequence motifs conserved in organisms ranging from bacteria to humans. Bacterial, yeast and mammalian sirtuins are able to metabolize NAD and possibly at as mono-ADP-ribosyltransferases. The enzymatic function of sirtuins is not yet completely understood but recent reports of histone-activated Sir2-mediated NAD metabolism and NAD-activated Sir2-mediated histone deacetylation suggest a possible coupled reciprocal activation mechanism involving interactions of Sir2 with NAD and the N epsilon-acetyl-lysine groups of acetylated histones.Synonyms: NAD-dependent deacetylase sirtuin-7, S.cerevisiae, SIR2-like protein 7, SIR2L7, SIRT-7, homolog) 7, sirtuin (silent mating type information regulation 2, sirtuin 7, sirtuin type 7, sirtuin-7

Gen-ID: 51547

NCBI Accession: NP_057622

UniProt: Q9NRC8