Retinoic Acid Receptor alpha Antikörper (N-Term)

Produktnummer ABIN371837

Der Maus Monoklonal Anti-Retinoic Acid Receptor alpha-Antikörper wurde für WB validiert. Er ist geeignet, Retinoic Acid Receptor alpha in Proben von Human, Maus, Rind (Kuh) und Hund zu detektieren.

Kurzübersicht für Retinoic Acid Receptor alpha Antikörper (N-Term) (ABIN371837)

Target: Retinoic Acid Receptor alpha (RARA) (Retinoic Acid Receptor, alpha (RARA))

Reaktivität: Human, Maus, Rind (Kuh), Hund

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Retinoic Acid Receptor alpha Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 763

Produktdetails anti-Retinoic Acid Receptor alpha Antikörper

Bindungsspezifität: N-Term

Spezifität: This antibody is specific for the ~48k RAR-alpha isotype.

Kreuzreaktivität (Details): Species reactivity (expected):Bovine, Canine (Dog) and Mouse.
Species reactivity (tested):Human.

Produktmerkmale: Synonyms: NR1B1, Retinoic acid receptor alpha, Nuclear receptor subfamily 1 group B member 1

Aufreinigung: Prepared from Mouse Ascites by Ammonium Sulfate Precipitation followed by Affinity Chromatography on Protein G.

Immunogen: Peptide corresponding to amino acid residues from the N-terminal region of humanretinoic acid receptor, alpha-isotype.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western Blot: 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody undiluted (in aliquots) at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu Retinoic Acid Receptor alpha

Target: Retinoic Acid Receptor alpha (RARA) (Retinoic Acid Receptor, alpha (RARA))

Andere Bezeichnung: RAR-alpha / RARA

Hintergrund: Retinoic acid (RA, active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells (Joshi et al., 2005). The retinoid X receptors (RXRs) family (RXR-alpha, beta and gamma), preferentially bind 9-cis-RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer (Abu et al., 2005). RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors (Lane and Bailey, 2005).Synonyms: NR1B1, Nuclear receptor subfamily 1 group B member 1, Retinoic acid receptor alpha

Gen-ID: 5914

UniProt: P10276

Pathways: Nuclear Receptor Transcription Pathway, Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, S100 Proteine