ABCA4 Antikörper

Produktnummer ABIN371821

Dieses Maus Monoklonal-Antikörper erkennt spezifisch ABCA4 in WB und IHC (fro). Er zeigt eine Reaktivität gegenüber Human, Maus, Rind (Kuh) und Xenopus laevis.

Kurzübersicht für ABCA4 Antikörper (ABIN371821)

Target: ABCA4 (ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4))

Reaktivität: Human, Maus, Rind (Kuh), Xenopus laevis

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ABCA4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Klon: 3F4

Produktdetails anti-ABCA4 Antikörper

Spezifität: This antibody reacts with ABCA4 (Rim Protein).

Kreuzreaktivität (Details): Species reactivity (tested):Bovine, Human, Mouse and Xenopus.

Produktmerkmale: Synonyms: ABCR, Stargardt disease protein, ATP-binding cassette sub-family A member 4,Retinal-specific ATP-binding cassette transporter

Aufreinigung: Protein G Chromatography.

Immunogen: Partially purified bovine 220-kDa disc rim protein.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry: 1/100. Western blotting: 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5) 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody undiluted (in aliquots) at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu ABCA4

Target: ABCA4 (ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4))

Andere Bezeichnung: ABCA4

Hintergrund: ABCA4 (ATP-binding cassette, sub-family A (ABC1), member 4, Rim Protein) is a member of the superfamily of ATP-binding cassette (ABC) transporters (Illing et al., 1997). ABC proteins transport various molecules across extra- and intracellular membranes. This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essential molecule across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease and are associated with retinitis pigmentosa-19 and age-related macular degeneration (Wiszniewski et al., 2003). Defects in ABCA4 are the cause of Stargardt disease type 1 (STGD1) (Molday et al., 2000). STGD is one of the most frequent causes of macular degeneration in childhood. Defects in ABCA4 are also known to cause fundus flavimaculatus (FFM), age-related macular degeneration type 2 (ARMD2) and cone-rod dystrophy type 3 (CORD3) (Klevering et al., 2005).Synonyms: ABCR, ATP-binding cassette sub-family A member 4, Retinal-specific ATP-binding cassette transporter, Stargardt disease protein

Gen-ID: 24

UniProt: P78363