TIMP4 Antikörper

Produktnummer ABIN371661

Dieses Anti-TIMP4-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von TIMP4 in WB, IF und IHC (fro). Geeignet für Human.

Kurzübersicht für TIMP4 Antikörper (ABIN371661)

Target: TIMP4 (TIMP Metallopeptidase Inhibitor 4 (TIMP4))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TIMP4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))

Klon: SB30c

Produktdetails anti-TIMP4 Antikörper

Spezifität: This antibody is specific to Human TIMP4.

Produktmerkmale: Synonyms: TIMP-4, Tissue inhibitor of metalloproteinases 4, Metalloproteinase inhibitor 4

Aufreinigung: Purified

Immunogen: Recombinant TIMP-4.

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Western Blot: Detects a band of approximately 26 kDa (predicted Mol. Weight: 26 kDa). Immunohistochemistry on Frozen Sections. Immunocytochemistry/Immunofluorescence: Use at 5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: 100 mM Borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu TIMP4

Target: TIMP4 (TIMP Metallopeptidase Inhibitor 4 (TIMP4))

Andere Bezeichnung: TIMP4

Hintergrund: The MMPs and TIMPs can be divided into two groups with respect to gene expression: the majority exhibit inducible expression and a small number are produced constitutively or are expressed at very low levels and are not inducible. Among agents that induce MMP and TIMP production are the inflammatory cytokines TNF alpha and IL1 beta. A marked cell type specificity is a hallmark of both MMP and TIMP gene expression (i.e. a limited number of cell types can be induced to make these proteins). Tissue Inhibitor of Metalloproteinases 4 (TIMP4) was identified by molecular cloning. TIMP4 shows 37 % amino acid identity with TIMP1 and 51 % homology with TIMP2 and TIMP3. TIMP4 is secreted extracellularly, predominantly in heart and brain tissue. It may function in a tissue specific fashion in extracellular matrix (ECM) homeostasis. TIMP4 has a strong inhibitory effect on the invasion of human breast cancer cells across reconstituted basement membranes suggesting that TIMP4 may have an important role in inhibiting primary tumor growth and progression. The human TIMP4 gene has the chromosomal location of 3p25.Synonyms: Metalloproteinase inhibitor 4, TIMP-4, Tissue inhibitor of metalloproteinases 4

Gen-ID: 7079

UniProt: Q99727