MMP1 Antikörper (HRP)

Produktnummer ABIN371652

Produktdetails anti-MMP1 Antikörper (HRP)

Target: MMP1 (Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MMP1 Antikörper ist konjugiert mit HRP

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Spezifität: This antibody is specific for Human MMP-1. Does not cross react to human MMP-2, MMP-3 or MMP-9.

Produktmerkmale: Synonyms: Interstitial collagenase, Matrix metalloproteinase-1, Fibroblast collagenase, MMP1, CLG

Immunogen: Recombinant MMP-1.

Klon: SB12e

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: ELISA: 1/1,000-1/4,000. Western Blot. Immunohistochemistry (Frozen/Paraffin): 1/1,000-1/2,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 50 % Glycerol/50 % PBS, pH 7.4 without preservatives.

Konservierungsmittel: Without preservative

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or in (aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu MMP1

Target: MMP1 (Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1))

Andere Bezeichnung: MMP-1 (MMP1 Produkte)

Synonyme: CLG antikoerper, CLGN antikoerper, Mmp1a antikoerper, CG4859 antikoerper, Dm1-MMP antikoerper, Dmel\\CG4859 antikoerper, MMP-1 antikoerper, MMP1 antikoerper, Mmp 1 antikoerper, dMMP1 antikoerper, dm1-MMP antikoerper, dmmp1 antikoerper, l(2)k04809 antikoerper, mmp1 antikoerper, Mmp1 antikoerper, Mcol-A antikoerper, Mcola antikoerper, col4 antikoerper, mmp18 antikoerper, Clgn antikoerper, matrix metallopeptidase 1 antikoerper, Matrix metalloproteinase 1 antikoerper, matrix metalloproteinase 1 antikoerper, matrix metallopeptidase 1 (interstitial collagenase) antikoerper, matrix metallopeptidase 1a (interstitial collagenase) antikoerper, matrix metallopeptidase 1 S homeolog antikoerper, interstitial collagenase antikoerper, matrix metallopeptidase 8 L homeolog antikoerper, MMP1 antikoerper, Mmp1 antikoerper, RB11133 antikoerper, Mmp1a antikoerper, mmp1.S antikoerper, LOC100727966 antikoerper, mmp8.L antikoerper

Hintergrund: The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane bound zincendopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. In general, a signal peptide, a propeptide, and a catalytic domain containing the highly conserved zinc binding site characterizes the structure of the MMPs. In addition, fibronectin like repeats, a hinge region, and a C terminal hemopexin like domain allow categorization of MMPs into the collagenase, gelatinase, stomelysin and membrane type MMP subfamilies. All MMPs are synthesized as proenzymes, and most of them are secreted from the cells as proenzymes. Thus, the activation of these proenzymes is a critical step that leads to extracellular matrix breakdown. MMPs are considered to play an important role in wound healing, apoptosis, bone elongation, embryo development, uterine involution, angiogenesis and tissue remodeling, and in diseases such as multiple sclerosis, Alzheimer's, malignant gliomas, lupus, arthritis, periodontis, glumerulonephritis, atherosclerosis, tissue ulceration, and in cancer cell invasion and metastasis. MMP1, also known as interstitial collagenase, is the only enzyme that is able to initiate the breakdown of the interstitial collagens, types I, II, and IIISynonyms: CLG, Fibroblast collagenase, Interstitial collagenase, MMP1, Matrix metalloproteinase-1

Gen-ID: 4312

UniProt: P03956