CD32/CD16 Antikörper

Produktnummer ABIN370923

Produktdetails anti-CD32/CD16 Antikörper

Target: CD32/CD16

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser CD32/CD16 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Functional Studies (Func)

Produktmerkmale: Synonyms: IgG Fc receptor III-2, Fc-gamma RIII-alpha, Fc-gamma RIIIa, FcRIIIa, Fc-gamma RIII, FcRIII,CD16a, FcR mouse Seroblock, FCGR3A, FCG3, IGFR3, Fc gamma receptor IIB, Fc-gamma-RIIB,FcRII, Ly-17, Fcgr2, Lymphocyte antigen 17, IgG Fc receptor II beta, Low affinityimmunoglobulin gamma Fc region receptor II/III

Aufreinigung: Purified

Klon: 93

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Flow Cytometry: < / 3 μg/10^6 cells. (Ref.4,7,8)Functional Assay: Blocking of Fc-gamma receptors (< / 3 μg/10^6 cells).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: 100 mM Borate Buffered Saline, pH 8.2. No preservatives or amine-containing buffer salts added.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu CD32/CD16

Target: CD32/CD16

Andere Bezeichnung: CD16/CD32 (CD32/CD16 Produkte)

Hintergrund: The lymphocyte Fc-gamma Receptors recognize the Fc portion of IgG, presented either as immune complexes or as free antibody. The different classes of receptors are distinct because of varying size, tissue distribution and affinity for IgGs. The Fc type II receptor is expressed on a wide variety of cells including B cells, hematopoietic cells, monocyte/macrophages, neutrophils, platelets, Langerhans cells, eosinophils, basophils, trophoblasts, and endothelial cells of the placenta. (Ref.1,2) The Fc-gamma type III receptors are higher affinity than the type II and are expressed on macrophages, NK cells and neutrophils. Both types of receptors can be expressed on the same cell and in varying ratios. (Ref.1) The receptors are constitutively expressed, although cytokines and lymphokines can modulate their expression. (Ref.4) Besides identifying Fc-gammaR+ cells, monoclonal antibodies to the Fc-gammaII/III receptor have been used to block Fc receptor binding of IgG, Fcmediated signal transduction and effector functions, clearance of immune complexes and to attenuate infection by organisms dependent on Fc-gamma R for parasitic invasion. (Ref.4-6)Synonyms: CD16a, FCG3, FCGR3A, Fc gamma receptor IIB, Fc-gamma RIII, Fc-gamma RIII-alpha, Fc-gamma RIIIa, Fc-gamma-RIIB, FcR mouse Seroblock, FcRII, FcRIII, FcRIIIa, Fcgr2, IGFR3, IgG Fc receptor II beta, IgG Fc receptor III-2, Low affinity immunoglobulin gamma Fc region receptor II/III, Ly-17, Lymphocyte antigen 17