SIRT6 Antikörper (C-Term)
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- Target Alle SIRT6 Antikörper anzeigen
- SIRT6 (Sirtuin 6 (SIRT6))
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Bindungsspezifität
- AA 300-355, C-Term
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser SIRT6 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
- Spezifität
- Reacts with human SIRT6 protein
- Kreuzreaktivität (Details)
- 72 % sequence identity with rat.
- Aufreinigung
- Antigen affinity purified
- Immunogen
- Synthetic peptide made to a C-terminal region of the human SIRT6 protein (within residues 300-355)
- Top Product
- Discover our top product SIRT6 Primärantikörper
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anti-Sirtuin 6 (SIRT6) (AA 1-334) antibody
SIRT6 Reaktivität: Maus WB, IHC, IP, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Sirtuin 6 (SIRT6) (AA 141-250) antibodySIRT6 Reaktivität: Human WB, ELISA, IHC, ICC, FACS Wirt: Maus Monoclonal 2G1H1 unconjugated
anti-Sirtuin 6 (SIRT6) antibodySIRT6 Reaktivität: Human, Maus, Ratte, Affe WB, IP, IF Wirt: Maus Monoclonal 6C9-D10-D3 unconjugated
anti-Sirtuin 6 (SIRT6) (AA 290-319), (C-Term) antibodySIRT6 Reaktivität: Human, Maus WB, IHC (p) Wirt: Kaninchen Polyclonal RB2109 unconjugated
anti-Sirtuin 6 (SIRT6) (N-Term) antibodySIRT6 Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Schwein, Meerschweinchen, Pferd WB Wirt: Kaninchen Polyclonal unconjugated
anti-Sirtuin 6 (SIRT6) (Middle Region) antibodySIRT6 Reaktivität: Human, Ratte, Hund, Rind (Kuh) WB, IP, ChIP Wirt: Kaninchen Polyclonal unconjugated
anti-Sirtuin 6 (SIRT6) (AA 35-274) antibodySIRT6 Reaktivität: Human WB, IHC, IP, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Sirtuin 6 (SIRT6) (AA 56-105) antibodySIRT6 Reaktivität: Human, Maus, Hund, Affe, Schwein, Fledermaus, Hamster WB, IHC, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
anti-Sirtuin 6 (SIRT6) (AA 141-250) antibodySIRT6 Reaktivität: Human ELISA Wirt: Maus Monoclonal 1D8 unconjugated
anti-Sirtuin 6 (SIRT6) (C-Term) antibodySIRT6 Reaktivität: Human WB, IP Wirt: Kaninchen Polyclonal unconjugated
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- Applikationshinweise
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Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only:
- WB : 2 μg/mL - ICC/IF: 1:500 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1.05 mg/mL
- Buffer
- Tris-citrate, phosphate, ( pH 7-8) buffer, Sodium azide 0.1 %
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C
- Informationen zur Lagerung
- Store at 4°C. Do not freeze.
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- Target
- SIRT6 (Sirtuin 6 (SIRT6))
- Abstract
- SIRT6 Produkte
- Synonyme
- 2810449N18Rik antikoerper, AI043036 antikoerper, Sir2l6 antikoerper, SIR2L6 antikoerper, zgc:86729 antikoerper, sirtuin 6 antikoerper, sirtuin 6 S homeolog antikoerper, Sirt6 antikoerper, SIRT6 antikoerper, sirt6.S antikoerper, sirt6 antikoerper
- Hintergrund
- SIRT6 (SIR2-like protein 6) is a member of the yeast silent information regulator 2 (SIR2) family and possesses both strong ADP-ribosyltransferase activity as well as protein deacetylase activity which is dependent on NAD(+). SIRT6 exerts deacetylase activity towards histone H3K9Ac and H3K56Ac, and alters histone H3 acetylation in telomeric chromatin during cell cycle's S-phase. It deacetylates histone H3K9Ac at NFkB target promoters and downregulates a subset of NFkB target genes. Upon DNA damage, SIRT6 promotes DNA end resection via deacetylation of RBBP8. SIRT6 also serves as a corepressor of the transcription factor HIF1 alpha for regulating the expression of multiple glycolytic genes to control glucose homeostasis, and is required for normal IGF1 serum levels. SIRT6 play critical roles in maintaining telomere integrity, fine-tuning aging-associated gene expression programs, preventing genomic instability, and maintaining metabolic homeostasis, thus impacting on several pathways relevant for cancer, metabolism, aging, cellular senescence and apoptosis.
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