SIRT6 Antikörper (Internal Region)

Produktnummer ABIN363527

Produktdetails anti-SIRT6 Antikörper

Target: SIRT6 (Sirtuin 6 (SIRT6))

Bindungsspezifität: AA 250-350, Internal Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SIRT6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: Reacts with human SIRT6

Kreuzreaktivität: Maus, Ratte (Rattus)

Kreuzreaktivität (Details): Not tested in other species. The immunogen used for the production of this antibody shows 78 % homology with the mouse protein and 71 % homology with the rat protein.

Aufreinigung: Purified

Immunogen: Synthetic peptide made to an internal region of the human SIRT6 protein (within residues 250-350)

Anwendungsinformationen

Applikationshinweise:

Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only:
- WB : 0.5 to 2 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Tris-citrate, phosphate, ( pH 7-8) buffer, Sodium azide 0.1 %

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 4°C. Do not freeze.

Details zu SIRT6

Target: SIRT6 (Sirtuin 6 (SIRT6))

Abstract: SIRT6 Produkte

Synonyme: 2810449N18Rik antikoerper, AI043036 antikoerper, Sir2l6 antikoerper, SIR2L6 antikoerper, zgc:86729 antikoerper, sirtuin 6 antikoerper, sirtuin 6 S homeolog antikoerper, Sirt6 antikoerper, SIRT6 antikoerper, sirt6.S antikoerper, sirt6 antikoerper

Hintergrund: SIRT6 (SIR2-like protein 6) is a member of the yeast silent information regulator 2 (SIR2) family and possesses both strong ADP-ribosyltransferase activity as well as protein deacetylase activity which is dependent on NAD(+). SIRT6 exerts deacetylase activity towards histone H3K9Ac and H3K56Ac, and alters histone H3 acetylation in telomeric chromatin during cell cycle's S-phase. It deacetylates histone H3K9Ac at NFkB target promoters and downregulates a subset of NFkB target genes. Upon DNA damage, SIRT6 promotes DNA end resection via deacetylation of RBBP8. SIRT6 also serves as a corepressor of the transcription factor HIF1 alpha for regulating the expression of multiple glycolytic genes to control glucose homeostasis, and is required for normal IGF1 serum levels. SIRT6 play critical roles in maintaining telomere integrity, fine-tuning aging-associated gene expression programs, preventing genomic instability, and maintaining metabolic homeostasis, thus impacting on several pathways relevant for cancer, metabolism, aging, cellular senescence and apoptosis.