p300 Antikörper (AA 1572-2371)
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- Target Alle p300 (EP300) Antikörper anzeigen
- p300 (EP300) (E1A Binding Protein P300 (EP300))
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Bindungsspezifität
- AA 1572-2371
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Reaktivität
- Human, Maus, Ratte, Affe, Nerz
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser p300 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Spezifität
- Reacts with human p300 protein (residues 1868-1921)
- Kreuzreaktivität
- Maus
- Kreuzreaktivität (Details)
- Cross reacts with proteins from mouse, rat, monkey and mink.
- Aufreinigung
- Purified (protein A)
- Immunogen
- Fusion protein containing residues 1572-2371 of human p300
- Klon
- RW128
- Isotyp
- IgG1 kappa
- Top Product
- Discover our top product EP300 Primärantikörper
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- Applikationshinweise
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Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
ICC/IF1:10-1:2000, IP1:10-1:500, WB1:250-1:500 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- PBS, pH 7.4, Sodium azide 0.1 %
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C/-80 °C
- Informationen zur Lagerung
- Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
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- Target
- p300 (EP300) (E1A Binding Protein P300 (EP300))
- Andere Bezeichnung
- p300 (EP300 Produkte)
- Hintergrund
- Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability.
- Gen-ID
- 2033
- UniProt
- Q09472
- Pathways
- p53 Signalweg, Notch Signalweg, Interferon-gamma Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Regulation of Cell Size
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