HDAC5 Antikörper (AA 496-500)
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- Target Alle HDAC5 Antikörper anzeigen
- HDAC5 (Histone Deacetylase 5 (HDAC5))
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Bindungsspezifität
- AA 496-500
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser HDAC5 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC)
- Spezifität
- The antibody detects endogenous level of total HDAC5 protein.
- Aufreinigung
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific immunogen.
- Immunogen
- Peptide sequence around AA 496-500 (T-Q-S-S-P) derived from Human HDAC5, 7. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
- Isotyp
- IgG
- Top Product
- Discover our top product HDAC5 Primärantikörper
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- Applikationshinweise
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Western blotting: 1:500-1:1000
Immunohistochemistry: 1:50-1:100 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
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Fluid shear stress stimulates phosphorylation-dependent nuclear export of HDAC5 and mediates expression of KLF2 and eNOS." in: Blood, Vol. 115, Issue 14, pp. 2971-9, (2010) (PubMed).
: "GIT1 mediates HDAC5 activation by angiotensin II in vascular smooth muscle cells." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 28, Issue 5, pp. 892-8, (2008) (PubMed).
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Fluid shear stress stimulates phosphorylation-dependent nuclear export of HDAC5 and mediates expression of KLF2 and eNOS." in: Blood, Vol. 115, Issue 14, pp. 2971-9, (2010) (PubMed).
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- Target
- HDAC5 (Histone Deacetylase 5 (HDAC5))
- Andere Bezeichnung
- HDAC5 (HDAC5 Produkte)
- Synonyme
- HD5 antikoerper, NY-CO-9 antikoerper, AI426555 antikoerper, Hdac4 antikoerper, mHDA1 antikoerper, mKIAA0600 antikoerper, ATHDA5 antikoerper, HDA5 antikoerper, MAF19.7 antikoerper, MAF19_7 antikoerper, histone deacetylase 5 antikoerper, histone deacetylase 5 antikoerper, HDAC5 antikoerper, Hdac5 antikoerper, HDA05 antikoerper, hdac5 antikoerper
- Hintergrund
- Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by HDAC5 belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.
- Molekulargewicht
- 124 kDa
- NCBI Accession
- NP_001015
- UniProt
- Q9UQL6
- Pathways
- Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Monocarboxylic Acid Catabolic Process
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