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Histone H3.1 Antikörper (pSer10)

HIST1H3B Reaktivität: Human, Maus, Ratte WB, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN362204
  • Target Alle Histone H3.1 (HIST1H3B) Antikörper anzeigen
    Histone H3.1 (HIST1H3B)
    Bindungsspezifität
    • 15
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer10
    Reaktivität
    • 43
    • 18
    • 18
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 40
    • 3
    • 2
    Kaninchen
    Klonalität
    • 40
    • 5
    Polyklonal
    Konjugat
    • 33
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Histone H3.1 Antikörper ist unkonjugiert
    Applikation
    • 32
    • 25
    • 25
    • 16
    • 15
    • 8
    • 4
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
    Spezifität
    The antibody detects endogenous level of Histone H3.1 only when phosphorylated at serine 10.
    Aufreinigung
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removedby chromatography using non-phosphopeptide corresponding to the phosphorylation site.
    Immunogen
    Peptide sequence around phosphorylation site of pSer10 (R-K-S (p) -T-G) derived from Human Histone H3.1. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
    Isotyp
    IgG
    Top Product
    Discover our top product HIST1H3B Primärantikörper
  • Applikationshinweise
    Western blotting: 1:500-1:1000
    Immunohistochemistry: 1:50-1:100
    Immunofluorescence: 1:100-1:200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
  • Jiang, Li, Yang, Hawke, Zheng, Xia, Aldape, Wei, Guo, Chen, Lu: "PKM2 regulates chromosome segregation and mitosis progression of tumor cells." in: Molecular cell, Vol. 53, Issue 1, pp. 75-87, (2014) (PubMed).

    Liao, Dong, Wu, Yang, Wang, Guo, Chen, Xu, Wen: "Resolvin D1 attenuates inflammation in lipopolysaccharide-induced acute lung injury through a process involving the PPAR?/NF-?B pathway." in: Respiratory research, Vol. 13, pp. 110, (2013) (PubMed).

    Sun, Chen, Wang, Li, Xue, Qu, Zhang, Mu, Lu: "The protective effect of alpha lipoic acid on Schwann cells exposed to constant or intermittent high glucose." in: Biochemical pharmacology, Vol. 84, Issue 7, pp. 961-73, (2012) (PubMed).

    Yang, Xia, Hawke, Li, Liang, Xing, Aldape, Hunter, Alfred Yung, Lu: "PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis." in: Cell, Vol. 150, Issue 4, pp. 685-96, (2012) (PubMed).

  • Target
    Histone H3.1 (HIST1H3B)
    Andere Bezeichnung
    Histone H3.1 (HIST1H3B Produkte)
    Synonyme
    H3 histone antikoerper, Hist1h2ai antikoerper, histone cluster 1, H2ai-like1 antikoerper, histone H3.1 antikoerper, Hht21p antikoerper, Hist1h2ail1 antikoerper, H3.1 antikoerper, HHT21 antikoerper
    Hintergrund
    Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
    Molekulargewicht
    17 kDa
    NCBI Accession
    NP_003521
    UniProt
    P68431
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