ICAM1 Antikörper (pTyr512)
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- Target Alle ICAM1 Antikörper anzeigen
- ICAM1 (Intercellular Adhesion Molecule 1 (ICAM1))
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Bindungsspezifität
- pTyr512
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser ICAM1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Spezifität
- The antibody detects endogenous level of ICAM-1 only when phosphorylated at tyrosine 512.
- Aufreinigung
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removedby chromatography using non-phosphopeptide corresponding to the phosphorylation site.
- Immunogen
- Peptide sequence around phosphorylation site of pTyr512 (K-K-Y (p) -R-L) derived from Human ICAM-1. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
- Isotyp
- IgG
- Top Product
- Discover our top product ICAM1 Primärantikörper
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- Applikationshinweise
- Western blotting: 1:500-1:1000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
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- Target
- ICAM1 (Intercellular Adhesion Molecule 1 (ICAM1))
- Andere Bezeichnung
- ICAM-1 (ICAM1 Produkte)
- Synonyme
- BB2 antikoerper, CD54 antikoerper, P3.58 antikoerper, Icam-1 antikoerper, Ly-47 antikoerper, MALA-2 antikoerper, ICAM antikoerper, ICAM-1 antikoerper, ICAM1 antikoerper, intercellular adhesion molecule 1 antikoerper, intercellular adhesion molecule-1 antikoerper, ICAM1 antikoerper, Icam1 antikoerper, ICAM-1 antikoerper
- Substanzklasse
- Viral Protein
- Hintergrund
- ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin a-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.
- Molekulargewicht
- 92 kDa
- NCBI Accession
- NP_000192
- UniProt
- P05362
- Pathways
- Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis, Regulation of Leukocyte Mediated Immunity, Thromboxane A2 Receptor Signaling
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