ICAM1 Antikörper (pTyr512)
Kurzübersicht für ICAM1 Antikörper (pTyr512) (ABIN362032)
Target
Alle ICAM1 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- pTyr512
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Spezifität
- The antibody detects endogenous level of ICAM-1 only when phosphorylated at tyrosine 512.
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Aufreinigung
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removedby chromatography using non-phosphopeptide corresponding to the phosphorylation site.
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Immunogen
- Peptide sequence around phosphorylation site of pTyr512 (K-K-Y (p) -R-L) derived from Human ICAM-1. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
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Isotyp
- IgG
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Applikationshinweise
- Western blotting: 1:500-1:1000
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- 1 mg/mL
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Buffer
- Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C/-20 °C
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Informationen zur Lagerung
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
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- ICAM1 (Intercellular Adhesion Molecule 1 (ICAM1))
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Andere Bezeichnung
- ICAM-1
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Hintergrund
- ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin a-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.
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Molekulargewicht
- 92 kDa
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NCBI Accession
- NP_000192
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UniProt
- P05362
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Pathways
- Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis, Regulation of Leukocyte Mediated Immunity, Thromboxane A2 Receptor Signaling
Target
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