Der Kaninchen Polyklonal anti-Estrogen Receptor alpha Antikörper wird verwendet zum Nachweis von Estrogen Receptor alpha in Proben von Human und Maus. Er wurde validiert für WB, IHC und IF.
The antibody detects endogenous level of Estrogen Receptor-aonly when phosphorylated at serine 118.
Aufreinigung
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removedby chromatogramphy using non-phosphopeptide corresponding to the phosphorylation site.
Immunogen
Peptide sequence around phosphorylation site of pSer118 (Q-L-S (p) -P-F) derived from Human Estrogen Receptor-a. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.