TAO Kinase 2 Antikörper (pSer181)

Produktnummer ABIN361519

Produktdetails anti-TAO Kinase 2 Antikörper

Target: TAO Kinase 2 (TAOK2)

Bindungsspezifität: pSer181

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TAO Kinase 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: Specific for the ~120k TAO2 phosphorylated at Ser181 in Western blots. Immunolabeling is completely eliminated by treatment with phosphatase.

Kreuzreaktivität: Human, Maus, Ratte (Rattus)

Homologie: canine, finch, Xenopus, zebrafish

Aufreinigung: Antigen Affinity Purified from Pooled Serum

Immunogen: Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser181 conjugated to KLH

Anwendungsinformationen

Applikationshinweise: Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

Lagerung: -20 °C

Details zu TAO Kinase 2

Target: TAO Kinase 2 (TAOK2)

Andere Bezeichnung: TAOK2 (TAOK2 Produkte)

Synonyme: MAP3K17 antikoerper, PSK antikoerper, PSK1 antikoerper, PSK1-BETA antikoerper, TAO1 antikoerper, TAO2 antikoerper, Tao2 antikoerper, 1110033K02Rik antikoerper, B230344N16 antikoerper, mKIAA0881 antikoerper, TAOK2 antikoerper, map3k17 antikoerper, psk antikoerper, psk1 antikoerper, tao1 antikoerper, tao2 antikoerper, TAO kinase 2 antikoerper, TAO kinase 2 L homeolog antikoerper, serine/threonine-protein kinase TAO2 antikoerper, TAOK2 antikoerper, Taok2 antikoerper, taok2.L antikoerper, taok2 antikoerper, LOC100085396 antikoerper

Hintergrund: In vitro, TAO (thousand and one amino acid) protein kinase 2 (TAO2) activates MAP/ERK kinases (MEKs) 3, 4, and 6 toward their substrates p38 MAP kinase JNK/SAPK (Chen et al., 1999, Chen and Cobb, 2001). This and more recent work has led to the proposal that the TAO protein kinases play an essential role in signaling from physiological agonists to the stress-responsive p38 MAPKs (Chen et al., 2003). Autophosphorylation of TAO may play a role in the mechanism of TAO activation. The MEK binding domain of TAO is autophosphorylated on both serine and threonine residues and Ser181 is located within this domain. Anti-Phospho Ser181 TAO2 Western blot of rat cortex lysate showing specific immunolabeling of the ~120k TAO2 phosphorylated at Ser181 (Control). The phosphospecificity of this labeling is shown in the second lane (lambda-phosphatase: (-Ptase). The blot is identical to the control except that it was incubated in (-Ptase (1200 units for 30 min) before being exposed to the Ser181 TAO2 antibody. The immunolabeling is completely eliminated by treatment with (-Ptase.

Molekulargewicht: '120 kDa

Gen-ID: 9344

UniProt: Q9UL54

Pathways: Cell-Cell Junction Organization