GRIN2B Antikörper (pTyr1472)

Produktnummer ABIN361485

Zitiert in 6+ Publikationen. Dieser Anti-GRIN2B-Antikörper ist ein Kaninchen-Polyklonal-Antikörper zum Nachweis von GRIN2B in WB und ELISA. Geeignet für Ratte.

Kurzübersicht für GRIN2B Antikörper (pTyr1472) (ABIN361485)

Target: GRIN2B (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GRIN2B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-GRIN2B Antikörper

Bindungsspezifität: pTyr1472

Spezifität: Specific for endogenous levels of the ~180 kDa NMDAR NR2B-subunit protein phosphorylated at Tyr1472. Immunolabeling is completely eliminated by treatment with λ-phosphatase.

Kreuzreaktivität: Maus, Ratte

Homologie: bovine, canine, chicken, human, non-human primate, zebra fish

Produktmerkmale: Our NMDA NR2B Subunit (Tyr1472) rabbit polyclonal phosphospecific primary antibody is produced in-house. It detects NMDA NR2B Subunit (Tyr1472) and is antigen affinity purified from pooled serum. It is great for use in ELISA, WB.

Aufreinigung: Prepared from pooled rabbit serum by affinity purification via sequential chromatography on phospho and non-phosphopeptide affinity columns.

Immunogen: Synthetic phospho-peptide corresponding to amino acid residues surrounding Tyr1472 of the NR2B subunit of the rat NMDA receptor, conjugated to keyhole limpet hemocyanin (KLH).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Dilution Range: ICC: 1:100

Dilution Range: WB Brain: 1:1000

Dilution Range: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

Lagerung: -20 °C

Informationen zur Lagerung: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Haltbarkeit: 12 months

Referenzen für anti-GRIN2B Antikörper (ABIN361485)

Knox, Brennan-Minnella, Lu, Yang, Nakazawa, Yamamoto, Swanson, Ferriero, Jiang: "NR2B phosphorylation at tyrosine 1472 contributes to brain injury in a rodent model of neonatal hypoxia-ischemia." in: Stroke; a journal of cerebral circulation, Vol. 45, Issue 10, pp. 3040-7, (2014) (PubMed).

Gladding, Sepers, Xu, Zhang, Milnerwood, Lombroso, Raymond: "Calpain and STriatal-Enriched protein tyrosine phosphatase (STEP) activation contribute to extrasynaptic NMDA receptor localization in a Huntington's disease mouse model." in: Human molecular genetics, Vol. 21, Issue 17, pp. 3739-52, (2012) (PubMed).

Castillo, Norcini, Baquero-Buitrago, Levacic, Medina, Montoya-Gacharna, Blanck, Dubois, Recio-Pinto: "The NMDA-evoked cytoplasmic calcium increase in adult rat DRG neuronal somata was potentiated by SP pretreatment in a PKC-dependent manner." in: Neuroscience, (2011) (PubMed).

Carreño, Walch, Dutta, Nedungadi, Cunningham: "Brain-Derived Neurotrophic Factor-Tyrosine Kinase B Pathway Mediates NMDA Receptor NR2B Subunit Phosphorylation in the Supraoptic Nuclei Following Progressive Dehydration." in: Journal of neuroendocrinology, Vol. 23, Issue 10, pp. 894-905, (2011) (PubMed).

Venkitaramani, Moura, Picciotto, Lombroso: "Striatal-enriched protein tyrosine phosphatase (STEP) knockout mice have enhanced hippocampal memory." in: The European journal of neuroscience, Vol. 33, Issue 12, pp. 2288-98, (2011) (PubMed).

Hicklin, Wu, Radcliffe, Freund, Goebel-Goody, Correa, Proctor, Lombroso, Browning: "Alcohol inhibition of the NMDA receptor function, long-term potentiation, and fear learning requires striatal-enriched protein tyrosine phosphatase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 16, pp. 6650-5, (2011) (PubMed).

Details zu GRIN2B

Target: GRIN2B (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B))

Andere Bezeichnung: GRIN2B

Hintergrund:

Synonyms: EPND antibody, FESD antibody, GluN2A antibody, Glutamate [NMDA] receptor subunit epsilon-1 antibody, Glutamate receptor antibody, Glutamate receptor ionotropic N methyl D aspartate 2A antibody, GRIN 2A antibody, GRIN2A antibody, hNR2A antibody, LKS antibody, N methyl D aspartate receptor channel subunit epsilon 1 antibody, N Methyl D Aspartate Receptor Subtype 2A antibody, N methyl D aspartate receptor subunit 2A antibody, N-methyl D-aspartate receptor subtype 2A antibody, NMDA receptor subtype 2A antibody, NMDAR 2A antibody, NMDAR2A antibody, NMDE1_HUMAN antibody, NR2A antibody, OTTHUMP00000160135 antibody, OTTHUMP00000174531 antibody

Description Logic: Our NMDA NR2B Subunit (Tyr1472) rabbit polyclonal phosphospecific primary antibody is produced . It detects NMDA NR2B Subunit (Tyr1472) and is antigen affinity purified from pooled serum. It is great for use in ELISA, WB.

Gene Name Alternatives: GRIN2B

Molekulargewicht: 180 kDa

Gen-ID: 24410

UniProt: Q00960

Pathways: Response to Growth Hormone Stimulus, Synaptic Membrane, Feeding Behaviour, Regulation of long-term Neuronal Synaptic Plasticity