STXBP2 Antikörper (pSer513)

Produktnummer ABIN361480

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch STXBP2 in WB und IHC. Er zeigt eine Reaktivität gegenüber Ratte.

Kurzübersicht für STXBP2 Antikörper (pSer513) (ABIN361480)

Target: STXBP2 (Syntaxin Binding Protein 2 (STXBP2))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser STXBP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-STXBP2 Antikörper

Bindungsspezifität: pSer513

Spezifität: Specific for the ~65k Munc-18 protein phosphorylated at Ser515. Immunolabeling is blocked by the phosphopeptide used as antigen but not by the corresponding dephosphopeptide.

Kreuzreaktivität: Ratte (Rattus)

Homologie: bovine, canine, chicken, human, mouse, non-human primate, Xenopus

Aufreinigung: Antigen Affinity Purified from Pooled Serum

Immunogen: Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser513 conjugated to KLH

Anwendungsinformationen

Applikationshinweise: Recommended Dilution: WB: 1:1000 IHC: 1:400 Quality Control: Western blots performed on each lot.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

Lagerung: -20 °C

Details zu STXBP2

Target: STXBP2 (Syntaxin Binding Protein 2 (STXBP2))

Andere Bezeichnung: STXBP2

Hintergrund: Munc-18 ( mammalian homologue of Unc-18) is a protein that is thought to be involved in regulating exocytosis due, at least in part, to it ability to bind syntaxin (Ciufo et al., 2005). Munc18-1 is a neuron-specific member of the Sec1/Munc18 protein family that binds to syntaxin1A and is thought to stabilize the complex (Liu et al., 2004). The function of Munc-18 is thought to be regulated by PKC phosphorylation of Ser515 on the Munc-18 protein (Sassa et al., 1996). Anti-Phospho-Ser515 Munc-18 Western blot of rat cortex lysate showing specific immunolabeling of the ~65k Munc-18 protein phosphorylated at Ser515. Immunolabeling is blocked by the phosphopeptide (peptide) used as antigen but not by the corresponding dephosphopeptide (not shown). .

Molekulargewicht: '65 kDa

Gen-ID: 81804

UniProt: Q62753

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Synaptic Vesicle Exocytosis