SLC6A1 Antikörper (C-Term)

Produktnummer ABIN361450

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch SLC6A1 in WB und IHC. Er zeigt eine Reaktivität gegenüber Ratte.

Kurzübersicht für SLC6A1 Antikörper (C-Term) (ABIN361450)

Target: SLC6A1 (GAT1) (GABA Transporter 1 (GAT1))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SLC6A1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-SLC6A1 Antikörper

Bindungsspezifität: C-Term

Spezifität: Specific for the ~67k GAT-1 protein. Immunolabeling is blocked by the peptide used as antigen.

Kreuzreaktivität: Maus, Ratte (Rattus)

Aufreinigung: Affinity Purified

Immunogen: Synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH

Anwendungsinformationen

Applikationshinweise: Recommended Dilution: WB: 1:1000 IHC: 1:100-1:200 Quality Control: Western blots performed on each lot.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

Lagerung: -20 °C

Details zu SLC6A1

Target: SLC6A1 (GAT1) (GABA Transporter 1 (GAT1))

Andere Bezeichnung: SLC6A1

Hintergrund: Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABA plasma membrane transporters (GATs) influence synaptic neurotransmission by high-affinity uptake and release of GABA. To date, four distinct GABA transporters have been identified: GAT-1, GAT-2, GAT-3, and BGT-1. GAT-1, the most abundant of the transporters, is found predominantly in neurons, but also in some specialized glia (Minelli et al., 1995). GAT-1 is thought to play a key role in epileptogenesis (Zhao et al. 2003). Anti-GAT1 Western blot of rat hippocampal homogenate showing specific immunolabeling of the~ 67k GAT-1 protein.

Molekulargewicht: '67 kDa

Gen-ID: 79212

UniProt: P23978