GRIPAP1
Reaktivität: Human
IP
Wirt: Kaninchen
Polyclonal
unconjugated
Applikationshinweise
Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Buffer
100 μL in 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.
Lagerung
-20 °C
Target
GRIPAP1
(GRIP1 Associated Protein 1 (GRIPAP1))
Andere Bezeichnung
GRIPAP1
Hintergrund
PDZ domain-containing proteins, such as PSD-95 and GRIP are thought to play key roles in glutamate receptor plasticity. GRIP-associated proteins (GRASPs) that bind to distinct PDZ domains within GRIP also play key roles in regulation of glutamate receptor function. GRASP-1 is a neuronal rasGEF associated with GRIP and AMPA receptors in vivo (Scannevin and Huganir, 2000). Recent work suggests that GRASP-1 may regulate neuronal ras signaling and contribute to the regulation of AMPA receptor distribution by NMDA receptor activity (Ye et al., 2000). Anti-GRASP Western blot of rat cerebellar lysate showing the specific immunolabeling of the ~95k GRASP protein.