Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Buffer
100 μL in 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.
Lagerung
-20 °C
Erickson, Ray, Wink, Bayon, Pedapati, Shaffer, Schaefer, Lahiri: "Initial analysis of peripheral lymphocytic extracellular signal related kinase activation in autism." in: Journal of psychiatric research, Vol. 84, pp. 153-160, (2017) (PubMed).
Target
MAPK1/2
Hintergrund
Extracellular-Signal Regulated Kinase/Mitogen-Activated Protein Kinase (ERK/MAPK) is an integral component of cellular signaling during mitogenesis and differentiation of mitotic cells and also is thought to play a key role in learning and memory (Adams and Sweatt, 2002, Ahn, 1993, Tanoue and Nishida, 2003, Johnson and Lapadat, 2002). The activity of this kinase is regulated by dual phosphorylation at Thr202 and Tyr204 (Ahn, 1993). Anti-ERK/MAPK Western blot of rat hippocampal homogenate showing specific immunolabeling of ~42-44k ERK/MAPK protein.