Tyrosine Hydroxylase Antikörper

Produktnummer ABIN361414

Dieses Schaf Polyklonal-Antikörper erkennt spezifisch Tyrosine Hydroxylase in WB, IHC und IF. Er zeigt eine Reaktivität gegenüber Ratte.

Kurzübersicht für Tyrosine Hydroxylase Antikörper (ABIN361414)

Target: Tyrosine Hydroxylase (TH)

Reaktivität: Ratte

Wirt: Schaf

Klonalität: Polyklonal

Konjugat: Dieser Tyrosine Hydroxylase Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-Tyrosine Hydroxylase Antikörper

Spezifität: Specific for the ~60k tyrosine hydroxylase protein.

Kreuzreaktivität: Säugetier

Aufreinigung: Antigen Affinity Purified from Pooled Serum

Immunogen: SDS-denatured, native rat tyrosine hydroxylase purified from pheochromocytoma

Anwendungsinformationen

Applikationshinweise: Recommended Dilution: WB: 1:1000 IF (frozen sections, unpublished observations): 1:1000 IHC (frozen sections, unpublished observations): 1:1000 Quality Control: Western blots performed on each lot.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

Lagerung: -20 °C

Details zu Tyrosine Hydroxylase

Target: Tyrosine Hydroxylase (TH)

Andere Bezeichnung: Tyrosine Hydroxylase

Hintergrund: Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines dopamine and norepinephrine. TH antibodies can therefore be used as markers for dopaminergic and noradrenergic neurons in a variety of applications including depression, schizophrenia, Parkinson?s disease and drug abuse (Kish et al., 2001, Zhu et al., 2000, Zhu et al., 1999). TH antibodies can also be used to explore basic mechanisms of dopamine and norepinephrine signaling (Witkovsky et al., 2000, Salvatore et al., 2001). Anti-Tyrosine Hydroxylase Western blot of 10 ug of rat caudate lysate showing specific immunolabeling of the ~60k tyrosine hydroxylase protein.

Molekulargewicht: '60 kDa

Gen-ID: 25085

UniProt: P04177

Pathways: Dopaminergic Neurogenesis, Response to Water Deprivation, Sensory Perception of Sound, Carbohydrate Homeostasis, Feeding Behaviour